Relatedness severely impacts accuracy of marker-assisted selection for disease resistance in hybrid wheat

Heredity
Manje GowdaJochen C Reif

Abstract

The accuracy of genomic selection depends on the relatedness between the members of the set in which marker effects are estimated based on evaluation data and the types for which performance is predicted. Here, we investigate the impact of relatedness on the performance of marker-assisted selection for fungal disease resistance in hybrid wheat. A large and diverse mapping population of 1739 elite European winter wheat inbred lines and hybrids was evaluated for powdery mildew, leaf rust and stripe rust resistance in multi-location field trials and fingerprinted with 9 k and 90 k SNP arrays. Comparison of the accuracies of prediction achieved with data sets from the two marker arrays revealed a crucial role for a sufficiently high marker density in genome-wide association mapping. Cross-validation studies using test sets with varying degrees of relationship to the corresponding estimation sets revealed that close relatedness leads to a substantial increase in the proportion of total genotypic variance explained by the identified QTL and consequently to an overoptimistic judgment of the precision of marker-assisted selection.

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Citations

May 23, 2014·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·C Friedrich H LonginTobias Würschum
Nov 1, 2015·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jiaoping ZhangGuo-Liang Jiang
Jul 24, 2014·Trends in Plant Science·C Friedrich H Longin, Jochen C Reif
Sep 10, 2015·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Vilson MirditaYong Jiang
Apr 16, 2015·Journal of Experimental Botany·Yu WangYusheng Zhao
Nov 30, 2018·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Maximilian RembeJochen C Reif
Dec 21, 2016·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Sang HeYong Jiang
Nov 21, 2016·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Thomas MiedanerC Friedrich H Longin
Aug 23, 2018·Frontiers in Plant Science·Elsa SverrisdóttirKåre Lehmann Nielsen
Nov 20, 2016·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Yong JiangJochen C Reif
Jul 20, 2019·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Pushpendra Kumar GuptaArun Kumar Joshi
Mar 21, 2018·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias WürschumJochen C Reif
Dec 5, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Albert W SchulthessJochen C Reif
Apr 14, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Ulrike BeukertJochen C Reif
Feb 22, 2021·Genomics·Gopalareddy KrishnappaGyanendra Pratap Singh
Feb 20, 2021·Breeding Science·Motoyuki IshimoriHiroyoshi Iwata
Oct 12, 2021·Frontiers in Plant Science·Maximilian RembeYusheng Zhao

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