Relating Alpha Power and Phase to Population Firing and Hemodynamic Activity Using a Thalamo-cortical Neural Mass Model

PLoS Computational Biology
Robert BeckerViktor Jirsa

Abstract

Oscillations are ubiquitous phenomena in the animal and human brain. Among them, the alpha rhythm in human EEG is one of the most prominent examples. However, its precise mechanisms of generation are still poorly understood. It was mainly this lack of knowledge that motivated a number of simultaneous electroencephalography (EEG) - functional magnetic resonance imaging (fMRI) studies. This approach revealed how oscillatory neuronal signatures such as the alpha rhythm are paralleled by changes of the blood oxygenation level dependent (BOLD) signal. Several such studies revealed a negative correlation between the alpha rhythm and the hemodynamic BOLD signal in visual cortex and a positive correlation in the thalamus. In this study we explore the potential generative mechanisms that lead to those observations. We use a bursting capable Stefanescu-Jirsa 3D (SJ3D) neural-mass model that reproduces a wide repertoire of prominent features of local neuronal-population dynamics. We construct a thalamo-cortical network of coupled SJ3D nodes considering excitatory and inhibitory directed connections. The model suggests that an inverse correlation between cortical multi-unit activity, i.e. the firing of neuronal populations, and narrow band...Continue Reading

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Citations

Dec 5, 2015·Frontiers in Neuroinformatics·Henrik MatzkePetra Ritter
Feb 23, 2017·Consciousness and Cognition·Jason SamahaBradley R Postle
Mar 3, 2018·PLoS Computational Biology·Lauric A FerratJohn R Terry
Jun 25, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Constantinos Siettos, Jens Starke
May 16, 2019·Scientific Reports·Leandro JungesMarc Goodfellow
Feb 24, 2018·PLoS Computational Biology·Romesh G AbeysuriyaMark W Woolrich
May 6, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hugo GeertsAthan Spiros

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Software Mentioned

SPM
Matlab
TVB
SJ3D
MUA

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