Relating micromechanical properties and mineral densities in severely suppressed bone turnover patients, osteoporotic patients, and normal subjects.

Bone
Crystal TjhiaDavid P Fyhrie

Abstract

Mineralization of bone, from the tissue level to whole bones, is associated with mechanical properties. The relationship between bone tissue mineralization and micromechanical properties may be affected by age, disease, and drug treatment. Patients with severely suppressed bone turnover (SSBT) suffered atypical fractures while on bisphosphonate treatment. The role of tissue level mineralization in predicting material level properties of SSBT bone may be different from that of other osteoporotic patients and of normal subjects. The aim of this study was to compare the relationships between mineralization and micromechanical properties of bone biopsies from patients with SSBT, bisphosphonate-naive osteoporotic patients with typical vertebral fracture, and normal young and age-matched subjects. We used nanoindentation and quantitative backscattered electron microscopy to characterize the elastic modulus, contact hardness, plastic deformation resistance, and tissue mineralization of the biopsies at site-matched locations within each biopsy. The linear mineralization-mechanical property relationships were different among the groups with respect to the intercepts for only cortical bone tissue but not the slopes for cortical and trabe...Continue Reading

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Citations

Mar 13, 2014·Current Osteoporosis Reports·Per Aspenberg, Jörg Schilcher
Mar 5, 2015·Connective Tissue Research·Daniel RohrbachKay Raum
Jul 17, 2012·Current Medical Research and Opinion·Masataka ShirakiToshio Matsumoto
Oct 9, 2014·Annals of the New York Academy of Sciences·Michael PazianasMone Zaidi
May 17, 2013·Journal of Biomechanics·Ramin RasoulianIwona Jasiuk
Sep 24, 2013·Bone·M R HardistyD P Fyhrie
Jun 6, 2016·Current Osteoporosis Reports·Jeffry S NymanGeorge M Pharr
Jun 5, 2014·Current Osteoporosis Reports·Tamara Alliston
Jun 6, 2018·Current Osteoporosis Reports·Sabah Nobakhti, Sandra J Shefelbine
Jun 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Erik RettlerUlrich S Schubert
Jan 1, 2014·European Journal of Orthodontics·Nop M B K WillemsAndrej Zentner
Aug 28, 2013·JBJS Case Connector·Christopher W RebGregory K Deirmengian
Nov 30, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D PienkowskiH H Malluche
Mar 8, 2014·Journal of Biomedical Optics·Michael R HardistyDavid P Fyhrie

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