Relating pulmonary oxygen uptake to muscle oxygen consumption at exercise onset: in vivo and in silico studies.

European Journal of Applied Physiology
N LaiM E Cabrera

Abstract

Assessment of the rate of muscle oxygen consumption, UO(2m), in vivo during exercise involving a large muscle mass is critical for investigating mechanisms regulating energy metabolism at exercise onset. While UO(2m) is technically difficult to obtain under these circumstances, pulmonary oxygen uptake, VO(2p), can be readily measured and used as a proxy to UO(2m). However, the quantitative relationship between VO(2p) and UO(2m) during the nonsteady phase of exercise in humans, needs to be established. A computational model of oxygen transport and utilization--based on dynamic mass balances in blood and tissue cells--was applied to quantify the dynamic relationship between model-simulated UO(2m) and measured VO(2p) during moderate (M), heavy (H), and very heavy (V) intensity exercise. In seven human subjects, VO(2p) and muscle oxygen saturation, StO(2m), were measured with indirect calorimetry and near infrared spectroscopy (NIRS), respectively. The dynamic responses of VO(2p) and StO(2m) at each intensity were in agreement with previously published data. The response time of muscle oxygen consumption, tauUO(2m) estimated by direct comparison between model results and measurements of StO(2m) was significantly faster (P < 0.001) ...Continue Reading

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Citations

Mar 24, 2007·Annals of Biomedical Engineering·Nicola LaiMarco E Cabrera
Nov 15, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Regina EsterhammerAndreas Greiner
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Nicola LaiMarco E Cabrera
Oct 3, 2008·American Journal of Physiology. Cell Physiology·Yanjun LiMarco E Cabrera
Jan 1, 2008·Drug Discovery Today. Disease Models·Nicola LaiMarco E Cabrera
Jun 15, 2007·Journal of Theoretical Biology·Jenni HeinoErkki Somersalo
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Apr 1, 2008·Annals of the New York Academy of Sciences·Haiying ZhouMarco E Cabrera
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Apr 9, 2008·IEEE Transactions on Bio-medical Engineering·Ranjan K DashMarco E Cabrera
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Jun 14, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica SpiresNicola Lai
Jun 15, 2013·Journal of Applied Physiology·Alan P BensonHarry B Rossiter

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