Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy.

Translational Vision Science & Technology
Selin L AuvazianMahnaz Shahidi

Abstract

Diabetic retinopathy (DR) is a common cause of vision loss in working age adults and presents changes in retinal vessel oxygenation and morphology. The purpose of this study was to test the hypothesis that there is an association of retinal vessel oxygen saturation with vessel density (VD) and tortuosity in DR. Ninety-five subjects were classified in the following groups: nondiabetic control (N = 25), no DR (N = 28), mild nonproliferative DR (NPDR; N = 21), moderate to severe NPDR (N = 14), or treated proliferative DR (PDR; N = 7). Retinal oximetry was performed to measure arterial and venous oxygen saturation (SO2A and SO2V) and calculate oxygen extraction fraction (OEF). Optical coherence tomography angiography (OCTA) was performed for measurements of VD and vessel tortuosity index (VTI). There were statistically significant differences in SO2A and SO2V among groups (P ≤ 0.004). SO2A and SO2V were higher in the PDR group compared to the control group and SO2V was also higher in the moderate to severe NPDR group. VD differed significantly among groups (P = 0.003), whereas VTI was not significantly different (P = 0.22). Compared to the control group, VD was lower in moderate to severe NPDR and PDR groups. VD was also lower in t...Continue Reading

References

Feb 24, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M H CuypersB C Polak
Jan 1, 2003·Survey of Ophthalmology·Thomas W GardnerSteven W Levison
Jun 7, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E M CastilhoJ C Manço
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Apr 14, 2004·Archives of Ophthalmology·Monique S RoyJohn H Kempen
Apr 14, 2004·Archives of Ophthalmology·John H KempenUNKNOWN Eye Diseases Prevalence Research Group
Oct 11, 2005·Neuro-oncology·Gabriele Bergers, Steven Song
Mar 15, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Angelo AvogaroSaula de Kreutzenberg
May 1, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Martin HammerJürgen Strobel
Aug 12, 2010·JAMA : the Journal of the American Medical Association·Xinzhi ZhangRonald Klein
Nov 15, 2011·The British Journal of Ophthalmology·Sveinn Hakon Hardarson, Einar Stefánsson
Dec 29, 2012·High Altitude Medicine & Biology·Ian J C MacCormickBal Dhillon
Aug 31, 2013·Diabetes & Metabolism Journal·Jae-Seung YunYu-Bae Ahn
Oct 12, 2013·Investigative Ophthalmology & Visual Science·Bahram KhoobehiJames Beach
Dec 12, 2013·Investigative Ophthalmology & Visual Science·Yuki MuraokaNagahisa Yoshimura
Mar 13, 2014·Investigative Ophthalmology & Visual Science·Heather E MossMahnaz Shahidi
Oct 16, 2015·Investigative Ophthalmology & Visual Science·Anthony E FelderMahnaz Shahidi
Nov 17, 2015·Investigative Ophthalmology & Visual Science·Faryan TayyariChristopher Hudson
Nov 27, 2015·The Journal of Physiology·Richard W ChengChris Hudson
Oct 22, 2016·Investigative Ophthalmology & Visual Science·Anthony E FelderMahnaz Shahidi
Sep 8, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yoshihiro KaizuKoh-Hei Sonoda
Dec 26, 2018·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Abdullah S Al-Kharashi

❮ Previous
Next ❯

Software Mentioned

ImageJ
Statistical Analysis System ( SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.