Relating Stool Microbial Metabolite Levels, Inflammatory Markers and Dietary Behaviors to Screening Colonoscopy Findings in a Racially/Ethnically Diverse Patient Population

Genes
Kristina M BridgesChristina M Hester

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer death for both men and women in the United States, yet it is treatable and preventable. African Americans have higher incidence of CRC than other racial/ethnic groups, however, it is unclear whether this disparity is primarily due to environmental or biological factors. Short chain fatty acids (SCFAs) are metabolites produced by bacteria in the colon and are known to be inversely related to CRC progression. The aim of this study is to investigate how stool SCFA levels, markers of inflammation in stool and dietary intake relate to colonoscopy findings in a diverse patient population. Stool samples from forty-eight participants were analyzed for SCFA levels and inflammatory markers (lysozyme, secretory IgA, lactoferrin). Additionally, participants completed the National Cancer Institute's Diet History Questionnaire II (DHQ II) to report dietary intake over the past year. Subsequently, the majority of participants underwent screening colonoscopy. Our results showed that African Americans had higher total levels of SCFAs in stool than other racial/ethnic groups, significantly lower intake of non-starchy vegetables and similar inflammatory marker expression and colonoscopy...Continue Reading

References

Jan 1, 1991·Oral Surgery, Oral Medicine, and Oral Pathology·C F StreckfusR C Strahl
May 11, 1999·The American Journal of Gastroenterology·S J O'KeefeP Owira
Oct 2, 2003·The Journal of Nutrition·Janet A Vogt, Thomas M S Wolever
Jul 2, 2004·Experimental Biology and Medicine·Mark M Huycke, H Rex Gaskins
Jun 30, 2005·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Roger B Johnson
Jul 28, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Claude C RoyEmile Levy
Dec 22, 2006·The Journal of Nutrition·Stephen J D O'KeefeTian van der Merwe
Apr 28, 2007·World Journal of Gastroenterology : WJG·Ichiro HirataRyoichi Matsuse
Dec 22, 2007·CA: a Cancer Journal for Clinicians·Elizabeth WardAhmedin Jemal
Mar 8, 2008·Current Opinion in Genetics & Development·Paola AllavenaAlberto Mantovani
May 16, 2009·Current Pharmaceutical Design·Ian R Rowland
Sep 18, 2010·Inflammatory Bowel Diseases·Janelle C Arthur, Christian Jobin
Dec 15, 2010·American Journal of Clinical Oncology·Athanasios ChalkiasVaggelogiannis Katergiannakis
Feb 8, 2011·PloS One·Iradj SobhaniJean P Furet
Jun 8, 2011·PloS One·Julian R MarchesiHarold Tjalsma
Oct 20, 2011·Genome Research·Mauro CastellarinRobert A Holt
Oct 20, 2011·Genome Research·Aleksandar D KosticMatthew Meyerson
Jul 21, 2012·Journal of Clinical Pathology·Roy A Sherwood
Jan 12, 2013·Digestive Diseases and Sciences·Seiji OhigashiHisashi Onodera
May 31, 2013·The American Journal of Clinical Nutrition·Junhai OuStephen J D O'Keefe
Feb 26, 2014·World Journal of Gastrointestinal Oncology·Huawei ZengMichael Bordonaro
Mar 20, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Rahat-RozenbloomT M S Wolever
Aug 12, 2014·Cancer Prevention Research·Joseph P ZackularPatrick D Schloss
Mar 12, 2015·World Journal of Gastroenterology : WJG·Christina M HesterBodduluri Haribabu
Apr 29, 2015·Nature Communications·Stephen J D O'KeefeErwin G Zoetendal
Jun 1, 2015·The Journal of Nutritional Biochemistry·Huawei ZengKatie M Reindl
Aug 27, 2015·World Journal of Gastroenterology : WJG·Yu-Hua LiQi-Bing Mei
May 4, 2016·Molecular Nutrition & Food Research·Scott J Bultman
Jun 14, 2016·Journal of Racial and Ethnic Health Disparities·Steven S CoughlinSelina A Smith
Sep 10, 2016·World Journal of Gastroenterology : WJG·Teng-Fei YinDong Wu
Nov 17, 2016·Nature Reviews. Gastroenterology & Hepatology·Stephen J D O'Keefe
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Aug 16, 2017·Gastroenterology·Hassan AshktorabJohn M Carethers

❮ Previous
Next ❯

Citations

Jul 11, 2019·Journal of the American College of Nutrition·Cherie GuillermoGertraud Maskarinec
Apr 3, 2019·Microbiome·Bashir HamidiAlexander V Alekseyenko
May 21, 2019·Family & Community Health·Ramona StoneRichard Crosby

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

* Calc
Diet
Diet * Calc generated

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.