Relating structural and functional brainstem connectivity to disease measures in epilepsy.

Neurology
Dario J EnglotVictoria L Morgan

Abstract

While epilepsy studies rarely examine brainstem, we sought to examine the hypothesis that temporal lobe epilepsy (TLE) leads to subcortical arousal center dysfunction, contributing to neocortical connectivity and neurocognitive disturbances. In this case-control study of 26 adult patients with TLE and 26 controls, we used MRI to measure structural and functional connectivity of the cuneiform/subcuneiform nuclei (CSC), pedunculopontine nucleus, and ventral tegmental area. Ascending reticular activating system connectivity patterns were related to neuropsychological and disease measures. Compared to controls, patients with TLE demonstrated reductions in ascending reticular activating system structural and functional connectivity, most prominently to neocortical regions (p < 0.05, unpaired t tests, corrected). While reduced CSC structural connectivity was related to impaired performance IQ and visuospatial memory, diminished CSC functional connectivity was associated with impaired verbal IQ and language abilities (p < 0.05, Spearman ρ, t tests). Finally, CSC structural connectivity decreases were quantitatively associated with consciousness-impairing seizure frequency (p < 0.05, Spearman ρ) and the presence of generalized seizures...Continue Reading

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Jun 21, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Dario J EnglotVictoria L Morgan

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Citations

Apr 27, 2019·ELife·Fu-Shan KuoDaniel K Mulkey
May 28, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Hernán F J GonzálezDario J Englot
Dec 31, 2019·Epilepsy Currents·Dario J Englot
Jan 25, 2020·Epilepsy Currents·Jana E JonesUNKNOWN NINDS/AES Benchmarks Stewards Committee
May 10, 2019·Frontiers in Neuroscience·Ze-Ka ChenZhi-Li Huang
Jan 20, 2021·CNS Neuroscience & Therapeutics·Shengyu FangTao Jiang
Dec 19, 2020·Epilepsy & Behavior : E&B·Kristin E WillsDario J Englot
Jan 15, 2021·Neurology·Hernán F J GonzálezDario J Englot
Jul 12, 2021·Epilepsia·Aileen McGonigalPatrick Chauvel
Jul 13, 2021·NeuroImage·Olivia K HarrisonRobert L Barry

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