Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.

PloS One
Johan KerkhofsLiesbet Geris

Abstract

During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.

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Jul 6, 2014·International Orthopaedics·Liesbet Geris
Oct 23, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Bart SmeetsHans Van Oosterwyck
Dec 3, 2014·Advanced Drug Delivery Reviews·J LeijtenF P Luyten
Jun 13, 2015·Scientific Reports·Stefan Karl, Thomas Dandekar
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Mar 21, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alan J MuellerPeter D Clegg
Aug 15, 2018·Scientific Reports·Jae Il JooKwang-Hyun Cho

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