Relation between Breast Cancer and High Glycemic Index or Glycemic Load: A Meta-analysis of Prospective Cohort Studies

Critical Reviews in Food Science and Nutrition
Patrick MulliePeter Boyle

Abstract

Breast cancer is the commonest form of cancer in women worldwide. It has been suggested that chronic hyperinsulinemia associated with insulin resistance plays a role in breast cancer etiology. To test the hyperinsulinemia hypothesis, a dietary pattern associated with a high glycemic index and glycemic load, both proxies for chronic hyperinsulinemia, should be associated with an increased risk of breast cancer. A meta-analysis restricted to prospective cohort studies was undertaken using a random effects model with tests for statistical significance, publication bias and heterogeneity. The metric for analysis was the risk of breast cancer in the highest relative to the lowest glycemic index and glycemic load dietary pattern. A dietary pattern with a high glycemic index was associated with a summary relative risk (SRR) of 1.05 (95% CI: 1.00, 1.11), and a high glycemic load with a SRR of 1.06 (95% CI: 1.00, 1.13). Adjustments for body mass index [BMI], physical activity and other lifestyle factors did not influence the SRR, nor did menopausal status and estrogen receptor status of the tumor. In conclusion, the current evidence supports a modest association between a dietary pattern with high glycemic index or glycemic load and the...Continue Reading

References

Mar 1, 1981·The American Journal of Clinical Nutrition·D J JenkinsD V Goff
Oct 1, 1995·The American Journal of Clinical Nutrition·K Foster-Powell, J B Miller
May 1, 1996·Journal of Endocrinological Investigation·V Papa, A Belfiore
Apr 1, 1997·Diabetes Care·J SalmerónW C Willett
Feb 12, 1998·BMJ : British Medical Journal·M EggerA N Phillips
Feb 27, 2001·Statistics in Medicine·P MacaskillL Irwig
Mar 27, 2001·International Journal of Cancer. Journal International Du Cancer·B D LiH Yu
Feb 12, 2002·Statistics in Medicine·Hans C van HouwelingenTheo Stijnen
Jun 26, 2002·The American Journal of Clinical Nutrition·Kaye Foster-PowellJanette C Brand-Miller
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jan 28, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan HigginbothamSimin Liu
Feb 19, 2004·Cancer Causes & Control : CCC·A Lindsay FrazierGraham A Colditz
Mar 31, 2004·American Journal of Epidemiology·Michelle D HolmesWalter C Willett
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Stephanie A Navarro SilveraThomas E Rohan
Oct 12, 2005·International Journal of Cancer. Journal International Du Cancer·Graham G GilesJohn L Hopper
Oct 9, 2007·The American Journal of Clinical Nutrition·Sabina SieriVittorio Krogh
Jan 8, 2008·The American Journal of Clinical Nutrition·Thomas M S WoleverJian Zhang
Mar 11, 2008·The American Journal of Clinical Nutrition·Alan W BarclayJennie C Brand-Miller
Dec 6, 2008·The American Journal of Clinical Nutrition·Wanqing WenWei Zheng
Mar 26, 2009·International Journal of Cancer. Journal International Du Cancer·Susanna C LarssonAlicja Wolk
Mar 5, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eleni LinosLindsay Frazier
Jan 12, 2011·Breast Cancer Research and Treatment·Jia-Yi Dong, Li-Qiang Qin

❮ Previous
Next ❯

Citations

Feb 16, 2017·The British Journal of Nutrition·Marcella MalavoltiMarco Vinceti
Jan 25, 2018·International Journal of Epidemiology·Lucie LécuyerMathilde Touvier
May 8, 2020·Nutritional Neuroscience·Seyed Mohammad MousaviAhmad Esmaillzadeh
Jan 19, 2016·Molecular Nutrition & Food Research·Henry J ThompsonAnne McTiernan
Sep 17, 2020·The American Journal of Clinical Nutrition·Charlotte DebrasMathilde Touvier
Dec 21, 2017·Food & Function·Daniela FreitasIsabelle Souchon
May 29, 2018·European Journal of Clinical Nutrition·Lu WangChanggang Sun
Jan 22, 2019·Current Breast Cancer Reports·Annina SeilerChristopher P Fagundes
Oct 5, 2019·Nutrients·Federica TuratiCarlo La Vecchia
Mar 22, 2019·Current Nutrition Reports·Christian A Maino VieytesAnna E Arthur
May 29, 2018·Cancer Causes & Control : CCC·Seungyoun JungJoanne F Dorgan
Jul 8, 2020·International Journal of Environmental Research and Public Health·Alessandra BujaVincenzo Baldo
Oct 7, 2020·The American Journal of Clinical Nutrition·Jae H KangA Heather Eliassen
Dec 16, 2020·International Journal of Cancer. Journal International Du Cancer·Santoshi MuppalaOlga Stenina-Adognravi
Apr 4, 2021·Cancers·Jasmine GajetonOlga Stenina-Adognravi
May 6, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Serena C Houghton, Susan E Hankinson
Nov 15, 2016·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Nicole S Carlson

❮ Previous
Next ❯

Software Mentioned

R
MOOSE

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

© 2022 Meta ULC. All rights reserved