Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research

BMJ : British Medical Journal
Petros IsaakidisJohn P A Ioannidis

Abstract

To evaluate whether the amount of randomised clinical research on various medical conditions is related to the burden of disease and health needs of the local populations in sub-Saharan Africa. Construction and analysis of comprehensive database of randomised controlled trials in sub-Saharan Africa based on Medline, the Cochrane Controlled Trials Register, and several African databases. Sub-Saharan Africa. Number of trials and randomised subjects for each category of disease in the global burden of disease taxonomy; ratios of disability adjusted life years (DALYs) per amount of randomised evidence. 1179 eligible randomised controlled trials were identified. The number of trials published each year increased over time. Almost half of the trials (n=565) had been done in South Africa. There was relatively good correlation between the estimated burden of disease at year 2000 and the number of trials performed (r=0.53, P=0.024) and the number of participants randomised (r=0.68, P=0.002). However,some conditions-for example, injuries (over 20 000 DALYs per patient ever randomised)-were more neglected than others. Despite recent improvements, few clinical trials are done in sub-Saharan Africa. Clinical research in this part of the wor...Continue Reading

References

Apr 13, 1991·Lancet·P J EasterbrookD R Matthews
Jan 1, 1986·Social Science & Medicine·D Taylor
Mar 15, 1995·Statistics in Medicine·I Olkin
Sep 19, 1997·The New England Journal of Medicine·G I Msamanga, W W Fawzi
Jan 7, 1998·BMJ : British Medical Journal·D E Logie, S R Benatar
Feb 5, 1998·JAMA : the Journal of the American Medical Association·J P Ioannidis
Mar 3, 1998·Lancet·G Walt
Jun 10, 1998·Lancet·I WolffersR van der Drift
Jun 17, 1999·The New England Journal of Medicine·C P GrossN R Powe
Jul 17, 1999·Lancet·P Trouiller, P L Olliaro
Feb 7, 2001·American Journal of Public Health·E G KrugR Lozano
Sep 29, 2000·Lancet·R Horton
Sep 29, 2000·BMJ : British Medical Journal·K Lee, A Mills
Sep 29, 2000·BMJ : British Medical Journal·A Costello, A Zumla

❮ Previous
Next ❯

Citations

Oct 16, 2004·Health Policy·Rachael L Fleurence, David J Torgerson
Jul 20, 2002·The Lancet Infectious Diseases·Alimuddin Zumla
Jul 10, 2003·Lancet Neurology·Phillipe Lacoux, Nathan Ford
May 7, 2010·Journal of Human Hypertension·P IsaakidisT Reid
Sep 11, 2008·International Journal of Epidemiology·Mary J De SilvaUNKNOWN CRASH Trial Collaborators
Oct 4, 2003·BMJ : British Medical Journal·Massey BeveridgeWarren Holder
Nov 8, 2003·BMJ : British Medical Journal·George H SwinglerJohn P A Ioannidis
Apr 10, 2004·BMJ : British Medical Journal·Ian Roberts, Kamran Abbasi
Oct 1, 2005·BMJ : British Medical Journal·Nandi SiegfriedJimmy Volmink
Nov 12, 2005·BMJ : British Medical Journal·Ian RobertsPeter Sandercock
Mar 21, 2006·BMJ : British Medical Journal·Nikolaos A PatsopoulosApostolos A Analatos
Dec 22, 2010·Population Health Metrics·Ferrán Catalá-LópezConsuelo Morant-Ginestar
Jan 19, 2005·Annals of Family Medicine·Walter W Rosser, Chris van Weel
Jan 19, 2005·Annals of Family Medicine·Bruce L W Sparks, Shatendra K Gupta
Oct 31, 2006·PLoS Clinical Trials·UNKNOWN CRASH-2 Trial Collaborators
Apr 3, 2014·PloS One·James A EvansJohn P A Ioannidis
Jul 25, 2012·Pediatrics·Florence T BourgeoisKenneth D Mandl
Mar 12, 2010·Paediatric Drugs·Khairun N B Nor AripinImti Choonara
Oct 12, 2010·Annals of African Medicine·K A Oshikoya, I O Senbanjo
Feb 25, 2011·Bulletin of the World Health Organization·Sarah E RosenbaumAndrew D Oxman
Dec 17, 2014·Globalization and Health·Janice C WongMonika K Krzyzanowska
Feb 9, 2010·Annals of Emergency Medicine·Renee HsiaJon Mark Hirshon
Jun 28, 2008·Seminars in Hematology·John P A Ioannidis
Sep 10, 2011·Journal of Evidence-based Medicine·Amber Abrams, Nandi Siegfried
Oct 20, 2010·Tropical Medicine & International Health : TM & IH·Charles MgoneNelson Sewankambo
May 13, 2014·Clinical and Translational Science·Marci D CottinghamJill A Fisher
Dec 27, 2005·American Journal of Preventive Medicine·David R MeddingsJoan Serra Hoffman
Dec 14, 2004·Social Science & Medicine·Nicola Wendy Barsdorf, Douglas Richard Wassenaar
Apr 17, 2015·Perspectives in Clinical Research·K HariohmJ Saravankumar
Feb 20, 2008·Clinical Trials : Journal of the Society for Clinical Trials·Deborah CookIan Roberts
Jun 11, 2014·Journal of the Royal Society of Medicine·Derege KebedePaul-Samson Lusamba-Dikassa
Aug 3, 2006·Journal of Community & Applied Social Psychology·Nosisana Nama, Leslie Swartz
May 2, 2014·Journal of Empirical Research on Human Research Ethics : JERHRE·Paul NdebeleEric M Meslin
Aug 3, 2013·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN Stroke Journal Editorial Board
Jan 30, 2019·PLoS Neglected Tropical Diseases·Chris A ReesFlorence T Bourgeois
Oct 2, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Graham Thornicroft, Michele Tansella
Mar 17, 2018·Health Research Policy and Systems·Loai AlbarqouniNiveen M E Abu-Rmeileh
Aug 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Massey Beveridge, Andrew Howard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.