PMID: 6113548Jan 1, 1980Paper

Relation between central sympathoinhibitory and peripheral pre- and postsynaptic alpha-adrenoceptors as evaluated by different clonidine-like substances in rats

Naunyn-Schmiedeberg's Archives of Pharmacology
W Kobinger, L Pichler

Abstract

A series of 8 clonidine-like substances were tested in rats on central sympathoinhibition (heart rate decrease in vagotomized rats, D50 = dose which decreased heart rate by 50 beats/min), peripheral postsynaptic activity (blood pressure increase in spinal rats, PD30 = dose which increased blood pressure 30 mm Hg) and peripheral presynaptic activity (inhibition of tachycardia as elicited by electrical stimulation in the spinal canal of pithed rats, ID50 = dose which inhibited for 50%). The D50, PD30 and ID50 were converted in moles/kg and the negative logarithms thereof were correlated. There was a good correlation between the central effect (D50) and both peripheral effects (PD30 and ID50, respectively; r = 0.89 and 0.91, respectively) provided one drug with low lipoid affinity was omitted from calculation (St 600). There was also good correlation between both peripheral effects (PD30 and ID50; r = 0.94) and this could be extended to other imidazolines which are not acting centrally as antihypertensives (oxymetazoline, naphazoline, St 91, tramazoline; r = 0.90). The results were interpreted by (1) the agonistic activity of the clonidine-like drugs mainly at alpha 2-adrenoceptors and (2) the presence of alpha 2-adrenoceptors at ...Continue Reading

References

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Sep 1, 1977·Life Sciences·S Berthelsen, W A Pettinger
Jan 1, 1978·Reviews of Physiology, Biochemistry and Pharmacology· Kobinger
Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·T Tanaka, K Starke
Dec 1, 1975·European Journal of Pharmacology·K StarkeT Endo
Oct 1, 1977·European Journal of Pharmacology·P B Timmermans, P A Van Zwieten
Nov 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·P B TimmermansP A van Zwieten
Jun 1, 1973·European Journal of Pharmacology·W Kobinger, A Walland

❮ Previous
Next ❯

Citations

Jan 1, 1983·Psychopharmacology·M J DeniardF V DeFeudis
Apr 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·Y SakakibaraI Muramatsu
Apr 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·J S GutkindM A Enero
Aug 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·A de JongeP A van Zwieten
Aug 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·L PichlerW Kobinger
Nov 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·N E AndénU Thornström
Sep 24, 1981·European Journal of Pharmacology·M C Koss
Apr 8, 1982·European Journal of Pharmacology·J W ConstantineR A Weeks
Nov 27, 1984·European Journal of Pharmacology·A G Ramage
Feb 26, 1985·European Journal of Pharmacology·A G Ramage, A Tomlinson
Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·C R Goodlett, M L Valentino
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P Johansson
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P Johansson
Mar 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·A M Nolan, W Erhardt
May 20, 2000·Neuropharmacology·Z Díaz-CabialeK Fuxe
Jul 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·R R RuffoloD D Miller
Sep 1, 1985·Clinical and Experimental Pharmacology & Physiology·A M HuchetH Schmitt
Jan 1, 1987·Pharmacology & Toxicology·T SjöbergK E Andersson
Sep 1, 1984·Hypertension·P A van ZwietenP B Timmermans
Jan 1, 1990·Annals of the New York Academy of Sciences·K DakshinamurtiM Viswanathan
Jan 1, 1983·Acta Pharmacologica Et Toxicologica·N E AndénU Thornström
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·T Baum, F T Becker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.