PMID: 8606277Mar 1, 1996Paper

Relation between chemosensitivity and the ventilatory response to exercise in chronic heart failure

Journal of the American College of Cardiology
T P ChuaA J Coats

Abstract

This study sought to establish the chemosensitivity of patients with chronic heart failure. The ventilatory response to exercise is often increased in patients with chronic heart failure, as characterized by the steeper regression slope relating minute ventilation to carbon dioxide output. We hypothesized that the sensitivity of chemoreceptors may be reset and may in part mediate the exercise hyperpnea seen in this condition. Hypoxic and peripheral hypercapnic chemosensitivity were studied in 38 patients with chronic heart failure (35 men, 3 women; mean [+/-SE] age 60.2 +/- 1.3 years; radionuclide left ventricular ejection fraction 25.7 +/- 2.3%) and 15 healthy control subjects (11 men, 4 women; mean age 54.9 +/- 3.0 years) using transient inhalations of pure nitrogen and single breaths of 13% carbon dioxide, respectively. The change in chemosensitivity during mild exercise (25 W) was assessed in the first 15 patients and all control subjects. Central hypercapnic chemosensitivity was also characterized in 25 patients and 10 control subjects by the rebreathing of 7% carbon dioxide in 93% oxygen. Cardiopulmonary exercise testing was performed in all subjects. Maximal oxygen consumption was 16.6 +/- 0.9 versus 29.7 +/- 2.2 mol/kg ...Continue Reading

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Citations

Oct 13, 2007·Heart Failure Reviews·Carlos Eduardo Negrao, Holly R Middlekauff
Nov 1, 1996·Journal of the American College of Cardiology·A L ClarkA J Coats
Jan 1, 1997·Journal of the American College of Cardiology·T P ChuaA J Coats
Jun 1, 1997·Journal of the American College of Cardiology·T P ChuaA J Coats
Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·G A MacGowanS Murali
Aug 18, 2004·Sleep Medicine Reviews·M T Naughton
Feb 5, 2000·The New England Journal of Medicine·I WilcoxC E Sullivan
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Feb 11, 2005·Postgraduate Medical Journal·A Rao, D Gray
Jun 28, 2008·Journal of Applied Physiology·Yu-Long LiHarold D Schultz
Feb 1, 2013·Pulmonary Medicine·Anna ApostoloPiergiuseppe Agostoni
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·P SolinM T Naughton
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Sep 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideki TsurugayaKoichi Taniguchi

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