Relation between exercise-induced myocardial ischemia as assessed by nitrogen-13 ammonia positron emission tomography and QT interval behavior in patients with right bundle branch block

The American Journal of Cardiology
T WatanabeT Katagiri

Abstract

Exercise-induced myocardial ischemia is difficult to detect with ST-T changes in patients with right bundle branch block (RBBB). We sought to predict exercise-induced myocardial ischemia with QT interval behavior during exercise in patients with RBBB. Twenty-two patients with angiographically proven coronary artery disease and RBBB and 9 healthy volunteers underwent nitrogen-13 ammonia positron emission tomography with bicycle ergometer exercise at a fixed workload of 25 W. Regional myocardial blood flow (RMBF) and electrocardiographic changes were measured both at rest and after 5 minutes of exercise. The QT interval was measured from the onset of the QRS complex to the offset of the T wave in lead V5. The deltaQT and deltaRMBF, which indicated values after 5 minutes of exercise minus values at rest, were negatively correlated (r = -0.74, p <0.001). Exercise-induced shortening of the QT interval (422 +/- 27 to 381 +/- 38 ms, p = 0.0020) was observed in 15 patients (group 1) and no change or prolongation (411 +/- 45 to 420 +/- 37 ms, p = NS) was observed in 7 patients (group 2). Multivessel disease was significantly more frequent but collateral circulation was significantly less in group 2 than in group 1 (p <0.01, p <0.05, res...Continue Reading

References

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Citations

Feb 22, 2005·International Journal of Cardiology·Yasushi AkutsuTakashi Katagiri
Jun 22, 2010·Scandinavian Journal of Medicine & Science in Sports·M J Lewis, A L Short
Aug 12, 2005·Current Opinion in Cardiology·Elena BiaginiDon Poldermans
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
Aug 24, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Graeme M PurdyCraig D Steinback
Nov 1, 2011·Journal of Molecular and Cellular Cardiology·Dirk J DunckerDaphne Merkus

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