PMID: 8594543Oct 1, 1995Paper

Relation between extracellular [K+], membrane potential and contraction in rat soleus muscle: modulation by the Na+-K+ pump

Pflügers Archiv : European journal of physiology
Simeon P CairnsTorben Clausen

Abstract

An increased extracellular K+ concentration ([K+]0) is thought to cause muscle fatigue. We studied the effects of increasing [K+]0 from 4mM to 8-14mM on tetanic contractions in isolated bundles of fibres and whole soleus muscles from the rat. Whereas there was little depression of force at a [K+]0 of 8-9mM, a further small increase in [K+]0 to 11-14mM resulted in a large reduction of force. Tetanus depression at 11mM [K+]0 was increased when using weaker stimulation pulses and decreased with stronger pulses. Whereas the tetanic force/resting membrane potential (EM) relation showed only moderate force depression with depolarization from -74 to -62mV, a large reduction of force occurred when EM fell to-53mV. The implications of these relations to fatigue are discussed. Partial inhibition of the Na+-K+ pump with ouabain (10(-6 )M) caused additional force loss at 11mM [K+]0. Salbutamol, insulin, or calcitonin gene-related peptide all stimulated the Na+-K+ pump in muscles exposed to 11mM [K+]0 and induced an average 26-33% recovery of tetanic force. When using stimulation pulses of 0.1ms, instead of the standard 1.0-ms pulses, force recovery with these agents was 41-44% which was significantly greater (P < 0.025). Only salbutamol ca...Continue Reading

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Citations

Jul 19, 2006·Pflügers Archiv : European journal of physiology·Didier X P Brochet, Philip D Langton
Dec 19, 2002·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·N A Dimitrova, G V Dimitrov
Sep 14, 2010·Acta Pharmacologica Sinica·Cui YangGeorge Pak-heng Leung
Feb 3, 2005·The Journal of General Physiology·Thomas H PedersenOle B Nielsen
Jun 19, 2003·The Journal of Physiology·Thomas Holm PedersenOle Baekgaard Nielsen
Apr 28, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Antony D KarelisPhillip F Gardiner
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ole Baekgaard Nielsen, Frank Vincenzo de Paoli
Oct 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jianhua LiLawrence I Sinoway
Mar 5, 2008·The Journal of Clinical Investigation·Lawrence J HaywardRobert H Brown
Oct 2, 2001·The Journal of Physiology·O B NielsenK Overgaard
Oct 14, 1998·The Journal of Physiology·O B NielsenT Clausen
Sep 4, 2004·The Journal of Physiology·Maarten Geert van EmstMaria Elisabeth Everts
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Jul 2, 2008·The Journal of Physiology·S P Cairns, M I Lindinger
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Sep 25, 2003·Physiological Reviews·Torben Clausen

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