PMID: 16613181Apr 15, 2006Paper

Relation between gene polymorphism and acute coronary syndrome

Nihon rinsho. Japanese journal of clinical medicine
Michiya Igase, Tetsuro Miki

Abstract

The acute coronary syndrome, consisting of myocardial infarction and unstable angina, is the most important manifestation of coronary disease and is characterized by atherosclerotic plaque disruption and coronary thrombosis. In the coronary vessel wall, this process contains abnormalities of extracellular matrix, fibrinolytic system, endothelial function, and, possibly, vascular inflammation. Potentially thousands of genes are relevant to this apparently complex disease. Although many risk factors are intercorrelated, raising the possibility of a higher level of genetic control by a small number of master genes that control fundamental physiological systems. Such genes are likely to be relevant to the combined processes of plaque instability and coronary thrombosis.

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
C P SpencerJ C Stevenson
© 2022 Meta ULC. All rights reserved