Relation between hemostatic variables and increase of common carotid intima-media thickness in patients with peripheral arterial disease

Stroke; a Journal of Cerebral Circulation
M CortellaroR Paoletti

Abstract

Increases in common carotid intima-media thickness (CC-IMT), as measured by B-mode ultrasonography, have been widely used in both population studies and clinical trials in the search for risk factors for early atherosclerosis progression and have been found to correlate with age and with high concentrations of low-density lipoprotein cholesterol, leukocytes, and hemoglobin. We have now investigated the relation between several baseline hemostatic and conventional risk factors and CC-IMT changes over 16 months in 64 patients with peripheral arterial disease randomly selected from the prospective PLAT study series. Samples from 24 patients (37.5%) who showed increases in CC-IMT during the follow-up period were compared with those from 40 (62.5%) in whom CC-IMT remained unchanged. Baseline conventional risk factors and coagulation variables were similar in the two groups except for higher plasma concentrations of von Willebrand factor (vWF) (178.3 +/- 53.6% versus 141.2 +/- 53.7%, P=.01) and factor VII (FVII) (133.9 +/- 36.4% versus 107.0 +/- 27.3%, P=.001) in the patients with increased CC-IMT. CC-IMT increase correlated positively with plasma levels of FVII (r=.31, P<.01) and vWF (r=.31, P<.01). Multiple stepwise regression anal...Continue Reading

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Citations

Oct 7, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yi GuoFukang Li
Jul 20, 2010·Journal of Thrombosis and Thrombolysis·David KarasekDalibor Novotny
Jul 26, 2005·Atherosclerosis·Mitchell S V ElkindShunichi Homma
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May 6, 2011·The New England Journal of Medicine·Julian Ilcheff BorissoffHugo ten Cate
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Mar 25, 2006·Clinical Chemistry·Marion FunkChristine Mannhalter

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