Abstract
Increases in common carotid intima-media thickness (CC-IMT), as measured by B-mode ultrasonography, have been widely used in both population studies and clinical trials in the search for risk factors for early atherosclerosis progression and have been found to correlate with age and with high concentrations of low-density lipoprotein cholesterol, leukocytes, and hemoglobin. We have now investigated the relation between several baseline hemostatic and conventional risk factors and CC-IMT changes over 16 months in 64 patients with peripheral arterial disease randomly selected from the prospective PLAT study series. Samples from 24 patients (37.5%) who showed increases in CC-IMT during the follow-up period were compared with those from 40 (62.5%) in whom CC-IMT remained unchanged. Baseline conventional risk factors and coagulation variables were similar in the two groups except for higher plasma concentrations of von Willebrand factor (vWF) (178.3 +/- 53.6% versus 141.2 +/- 53.7%, P=.01) and factor VII (FVII) (133.9 +/- 36.4% versus 107.0 +/- 27.3%, P=.001) in the patients with increased CC-IMT. CC-IMT increase correlated positively with plasma levels of FVII (r=.31, P<.01) and vWF (r=.31, P<.01). Multiple stepwise regression anal...Continue Reading
References
Dec 14, 1991·Lancet·G D Lowe
Dec 14, 1991·Lancet·B DonatiniT Jones
Nov 1, 1991·British Heart Journal·J H JanssonO Johnson
Oct 1, 1991·Atherosclerosis·M CortellaroL Tavazzi
Mar 30, 1991·BMJ : British Medical Journal·J T SalonenH Korpela
Feb 1, 1990·Atherosclerosis·R Salonen, J T Salonen
Oct 1, 1989·AJR. American Journal of Roentgenology·D H O'Leary, J F Polak
Sep 6, 1986·Lancet·T W MeadeS G Thompson
Apr 1, 1988·Atherosclerosis·A PoliR Paoletti
Mar 1, 1995·The American Journal of Cardiology·J R CrouseC D Furberg
Dec 1, 1994·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S AgewallB Fagerberg
Jan 1, 1994·European Journal of Vascular Surgery·A D Blann, C N McCollum
Apr 1, 1957·Acta Haematologica·A CLAUSS
Citations
Oct 7, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yi GuoFukang Li
Jul 20, 2010·Journal of Thrombosis and Thrombolysis·David KarasekDalibor Novotny
Jul 26, 2005·Atherosclerosis·Mitchell S V ElkindShunichi Homma
Mar 11, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J NuverJ A Gietema
Jun 25, 1999·Atherosclerosis·M HanefeldT Temelkova-Kurktschiev
Jul 21, 1998·Thrombosis Research·U C GargJ H Eckfeldt
Feb 16, 2000·Thrombosis Research·A D BlannC N McCollum
Feb 16, 2000·Thrombosis Research·M KodamaM Hori
May 6, 2011·The New England Journal of Medicine·Julian Ilcheff BorissoffHugo ten Cate
Mar 3, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hann-Yeh ShyuChun-Wen Cheng
Mar 25, 2006·Clinical Chemistry·Marion FunkChristine Mannhalter
Apr 11, 2007·Clinical Science·Jerilynn C PriorCharmaine B Dean
Jul 3, 2004·Vascular Medicine·Pavel Poredos