Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
A AmbroschH Lehnert

Abstract

Limited data are available on determinants of diabetic neuropathy as its pathogenesis is multifactorial. Since homocysteine exhibits toxic effects on vascular endothelial cells, the association between homocysteine and the prevalence of neuropathy in Type 2 diabetes mellitus was investigated. A total of 65 Type 2 diabetic patients were consecutively enrolled into the study. Neuropathy was diagnosed according to clinical symptoms, clinical examination, electrophysiological sensory testing and autonomic function testing. With regard to homocysteine-related parameters, plasma homocysteine, folate, vitamin B12, vitamin B6 and renal function (creatinine, ceratinine clearance, cystatin C) were measured, and the C677T polymorphism of the methylenetetrahydrofolate reductase gene was determined. Forty-three of the Type 2 diabetic patients were classified as suffering from neuropathy. Both patient groups were comparable with regard to demographic data, blood pressure, glucose metabolism, renal function and homocysteine-related vitamins. In contrast, homocysteine levels (P = 0.04) and the frequency of hyperhomocysteinemia (>or= 15 micromol/l) (P = 0.01) were significantly increased in neuropathic patients. In a logistic regression model w...Continue Reading

References

Jun 1, 1975·Metabolism: Clinical and Experimental·S H Mudd, J R Poole
Sep 1, 1991·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·B Vester, K Rasmussen
Dec 1, 1990·Diabetes/metabolism Reviews·S L Rabinowe
Nov 1, 1990·Journal of the American College of Cardiology·J J GenestM R Malinow
Dec 1, 1988·Journal of Neurochemistry·D G WeirJ M Scott
May 1, 1988·Diabetes/metabolism Reviews·D A GreeneA A Sima
Apr 1, 1986·The Journal of Clinical Investigation·G Starkebaum, J M Harlan
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P J DyckB Zimmerman
Oct 1, 1983·European Journal of Clinical Investigation·P G de GrootJ A van Mourik
May 1, 1980·Journal of Clinical Pathology·E WilliamsT Duckworth
Nov 15, 1995·JAMA : the Journal of the American Medical Association·O NygårdG Kvåle
Dec 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·C D AgardhB Hultberg
Jul 13, 1995·The New England Journal of Medicine·J PartanenM Uusitupa
Dec 1, 1994·Journal of Internal Medicine·L BrattströmB Hultberg
Dec 8, 1993·JAMA : the Journal of the American Medical Association·J SelhubI H Rosenberg
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jun 1, 1993·Alcoholism, Clinical and Experimental Research·B HultbergA Frank
Sep 1, 1995·Baillière's Clinical Haematology·D G Weir, J M Scott
Sep 1, 1995·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·E SchlüsselE F Elstner
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H StrackeK Federlin
Jan 1, 1997·Journal of Diabetes and Its Complications·P ValensiJ R Attali
Sep 26, 1997·Southern Medical Journal·V A FonsecaP Dandona
Dec 24, 1997·Diabetes Care·M A HofmannP P Nawroth

❮ Previous
Next ❯

Citations

Dec 18, 2001·Diabetes/metabolism Research and Reviews·B NazlielB Koçer
Aug 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Futoshi AnanHironobu Yoshimatsu
Jun 1, 2002·Ageing Research Reviews·Mark P MattsonWenzhen Duan
Mar 21, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N N Chan, P Vallance
Mar 29, 2008·Metabolic Syndrome and Related Disorders·A BeckerC D A Stehouwer
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Maya S P HuijbertsCoen D A Stehouwer
Dec 18, 2004·Critical Reviews in Clinical Laboratory Sciences·Michele Mussap, Mario Plebani
Feb 13, 2009·International Journal of Food Sciences and Nutrition·Afsaneh TalaeiAli Chehrei
May 22, 2008·Expert Opinion on Investigational Drugs·Yi-Fei Zhang, Guang Ning
Jun 22, 2013·Clinical and Experimental Hypertension : CHE·Huan ZhengMing Luo
Sep 9, 2006·Clinics in Podiatric Medicine and Surgery·David A FrancisBradley D Beasley
Jun 28, 2012·Journal of the Peripheral Nervous System : JPNS·Ricardo GonzálezJose T Real
Feb 6, 2010·Diabetes/metabolism Research and Reviews·R GonzálezR Carmena
Jul 11, 2006·Medical Hypotheses·Mark F McCarty
Apr 13, 2011·Diabetes Research and Clinical Practice·Li JianboWang Hongxing
May 30, 2008·Diabetes Care·Sharon G Bruce, T Kue Young
Sep 7, 2016·Diabetes Research and Clinical Practice·Cristina PolitiVincenza Spallone
Oct 18, 2014·Journal of Clinical Neurology·Ramin AnsariJin Jun Luo
Sep 27, 2019·Annals of Clinical and Translational Neurology·Yating ZhaoXu Liu
Dec 10, 2017·Pharmacological Reports : PR·Armita Kakavand HamidiMahsa M Amoli
Feb 26, 2016·Journal of Clinical Neuromuscular Disease·Varun Shandal, Jin Jun Luo
Nov 22, 2020·European Journal of Pharmacology·Guilherme Pegas Teixeira, Robson Xavier Faria
Jan 10, 2021·Metabolites·Marika CordaroDaniela Impellizzeri
Feb 24, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Johannes SteinRima Obeid

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