Relation between hormone replacement therapy in women and coronary artery disease estimated by electron beam tomography

American Heart Journal
V V McLaughlinS Rich

Abstract

Many studies have suggested that hormone replacement therapy reduces the risk of coronary heart disease. Electron beam tomography is a highly sensitive noninvasive method by which to detect coronary artery disease. Our objective was to investigate whether hormone replacement therapy had an effect on coronary artery disease as determined by electron beam tomography in postmenopausal women. Nine hundred fourteen self-referred postmenopausal women older than 50 years underwent electron beam tomography. Each woman completed a questionnaire regarding age, risk factors, menopausal status, and hormone replacement therapy. Women taking hormone replacement therapy were slightly younger (57.8 years) than those not (60.7 years). A significantly higher incidence of a family history of myocardial infarction and smoking history was found in the group taking hormone replacement therapy, whereas more diabetics were in the group not taking hormone replacement therapy. The mean total coronary artery scores for women receiving hormone replacement therapy and not receiving hormone replacement therapy were 54.2 and 86.2, respectively (p = 0.02). Independent predictive variables of a positive coronary artery calcium score with multiple logistic regr...Continue Reading

References

Aug 1, 1992·Journal of the American College of Cardiology·J K WilliamsT B Clarkson
Sep 15, 1991·Annals of Internal Medicine·E Barrett-Connor
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Mar 1, 1988·Annals of Internal Medicine·J M SullivanD M Mirvis
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
Oct 22, 1987·The New England Journal of Medicine·J Mohle-Boetani, A Whittemore
Jan 1, 1995·Journal of the American College of Cardiology·S DevriesS Rich
Aug 1, 1994·Journal of the American College of Cardiology·R C DetranoB H Brundage
Jan 1, 1996·Obstetrics and Gynecology·B EttingerC P Quesenberry
Feb 1, 1996·Journal of the American College of Cardiology·R DetranoJ Reed
Aug 15, 1996·The New England Journal of Medicine·F GrodsteinC H Hennekens

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Citations

May 7, 2008·Menopause : the Journal of the North American Menopause Society·Matthew A AllisonUNKNOWN Women's Health Initiative and Women's Health Initiative Coronary Artery Calcium Study Investigators
Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Enrique F SchistermanHoward Lewin
Feb 17, 2000·Journal of the American College of Cardiology·M NishinoR F Redberg
May 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Moeen AbedinLinda L Demer
Sep 26, 2003·Calcified Tissue International·L B TankòC Christiansen
Jan 26, 2005·Menopause : the Journal of the North American Menopause Society·Elizabeth Barrett-Connor, Gail A Laughlin
Feb 2, 2000·Current Opinion in Nephrology and Hypertension·M G Jakoby, C F Semenkovich
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Firas AkhrassTheodore Mazzone
Jun 5, 1998·Journal of Women's Health·W D Schlaff
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·R C Christian, L A Fitzpatrick
Mar 23, 2011·Angiology·George Koulaouzidis, Michael Henein
Apr 16, 2021·Endocrine Reviews·Valerie A FloresJoAnn E Manson

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