PMID: 53056Nov 1, 1975

Relation between infarct size and ventricular arrhythmia

British Heart Journal
R RobertsB E Sobel

Abstract

In order to determine whether ventricular arrhythmia is quantitatively related to infarct size estimated enzymatically we studied 31 patients with acute myocardial infarction without cargiogenic shock. Infarct size index was estimated from hourly serum creatine kinase (CK) changes during periods of 48 to 72 hours. Ventricular arrhythmia was quantified by automated analysis of continuous electrocardiographic recordings over a period of 20 hours with the use of the Argus/H computer system. Patients were classified into three groups according to infarct size index. Patients in all groups had similar average heart rate, blood pressure, serum potassium, and arterial pH and PCO2 values during the first 10 hours after admission. The total number of ventricular ectopic beats (VEB), frequency of couplets, and ventricular tachycardia, and peak rate of ventricular ectopic beats during the first 10 hours after admission were all related to infarct size index. For example, patients with small, medium, and large estimated infarct size averaged 26, 104, and 405 ventricular ectopic beats, respectively. These results suggest that the severity of ventricular arrhythmia early after myocardial infarction is related to the extent of myocardial inju...Continue Reading

References

Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·N BankaP L Wahi
Nov 1, 1988·The American Journal of Cardiology·T KuzuyaM Tada
Nov 12, 1986·European Journal of Pharmacology·R D Reynolds, B S Brown
Jan 1, 1984·Pharmacology & Therapeutics·E Winslow
Jan 5, 2002·Journal of the American College of Cardiology·Stefano SavonittoGUSTO-IIb Investigators
May 1, 1983·Journal of the American College of Cardiology·W GanzH J Swan
Aug 25, 1977·The New England Journal of Medicine
Jul 26, 1984·The New England Journal of Medicine·R RobertsW K Poole
Feb 1, 1979·Australian and New Zealand Journal of Medicine·R R HopeR Lazzara
May 1, 1981·British Heart Journal·J H JürgensenO Pedersen-Bjergaard
Oct 13, 2010·Circulation. Arrhythmia and Electrophysiology·Thomas CrawfordFrank Bogun
Apr 1, 1981·The Journal of Clinical Investigation·R P KarlsbergS S Sekhon
Jun 27, 1983·The American Journal of Medicine·R Roberts
Jun 1, 1990·The American Journal of Cardiology·D C SevillaG S Wagner
Jan 1, 1979·The American Journal of Cardiology·L H OpieW F Lubbe
Mar 1, 1978·The American Journal of Cardiology·A L GutovitzR Roberts
Feb 1, 1978·The American Journal of Cardiology·R H HelfantM M Bodenheimer
May 1, 1983·The American Journal of Cardiology·J L SmithR Roberts

Citations

Sep 1, 1971·The American Journal of Cardiology·B Surawicz
Oct 1, 1972·Circulation·B E SobelR D Yoder
Nov 1, 1971·The American Journal of Cardiology·T Killip
Nov 9, 1968·British Medical Journal·F H SpracklenM Petrie

Related Concepts

Arterial Blood pH Measurement
Macro-Creatine Kinase
Anti-Arrhythmia Agents
Myocardium
Serum Potassium Measurement
Myocardial Infarction
Creatine Kinase Measurement
Cardiomyopathies
Tachycardia, Ventricular
Paired Ventricular Premature Complexes

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