PMID: 9166020Apr 1, 1997Paper

Relation between insulin-like growth factor-I, body mass index, and clinical status in cystic fibrosis

Archives of Disease in Childhood
A M TaylorD B Dunger

Abstract

Despite improved nutrition and intensive treatment, subjects with cystic fibrosis have difficulty in maintaining anabolism during intercurrent infections, which can result in reduced body mass index and impaired skeletal growth. Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP3 are sensitive to changes in nutritional status. The aim of this study was to determine the relation between circulating concentrations of these peptides, body mass index, and clinical status in cystic fibrosis. Serum concentrations of IGF-I and IGFBP3 were measured in 197 subjects (108 males, 89 females; mean age 9.69 years, range 0.41-17.9 years) and these data were analysed with respect to body mass index, pubertal stage, and clinical status as assessed by Shwachman score and forced expiratory volume in one second (FEV1). The mean height SD score of the children studied was -0.2 (SD 1.14) and the body mass index SD score -0.26 (1.4). The body mass index SD score declined with increasing age (r = -0.18) and paralleled changes in IGF-I concentrations, which also declined. The IGF-I SD score (calculated from control data) correlated with age (r = -0.53). The abnormalities were most obvious during late puberty, when IGF-I and IGFBP3 conce...Continue Reading

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Citations

Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mark P RoganDavid A Stoltz
Feb 15, 2001·Journal of Pediatric Gastroenterology and Nutrition·V GulmansK de Meer
Dec 12, 2001·Journal of Pediatric Gastroenterology and Nutrition·J C BucuvalasR W Wilmott
Nov 13, 2003·Archives of Disease in Childhood·I Sermet-GaudelusG Lenoir
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·P TirakitsoontornD M Cooper
Jan 28, 2006·Pediatric Research·Lewis A RosenbergMitchell L Drumm
Feb 18, 2004·Sports Medicine·Matthias Hütler, Ralph Beneke
Aug 3, 2010·Folia Histochemica Et Cytobiologica·Wioleta UmławskaAnna Zielińska
Oct 7, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gianfranco AlicandroCarla Colombo
Mar 13, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marta RibasésBru Cormand
Dec 14, 1999·Clinical Endocrinology·A M TaylorD B Dunger
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Ruth ChinuckElizabeth Hendron
May 21, 2015·The Cochrane Database of Systematic Reviews·Vidhu ThakerBrian W Houston
Dec 18, 2018·The Cochrane Database of Systematic Reviews·Vidhu ThakerMelissa Putman
Jan 12, 2007·Hormone Research·Margaret C S BoguszewskiKerstin Albertsson-Wikland
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Aug 24, 2021·The Cochrane Database of Systematic Reviews·Vidhu ThakerMelissa Putman

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