PMID: 16628283Apr 22, 2006Paper

Relation between insulin resistance and hematological parameters in a Brazilian sample

Arquivos brasileiros de endocrinologia e metabologia
Vivian C M EllingerRicardo M R Meirelles

Abstract

It has already been demonstrated that insulin resistance (IR) is associated with the stimulation of erythroid progenitors and with increased levels of inflammation markers. Therefore, IR should also be associated with increased red blood cell (RBC) and white blood cell (WBC) count. The aim of this study is to demonstrate that IR is independently associated with altered hematological parameters in a Brazilian sample. We analyzed laboratorial exams from 925 subjects. All data on hematological parameters, insulin resistance (Homeostasis Model Assessment [HOMA]) and lipid levels were included in the analysis. Demographic information included age and gender. HOMA correlated positively with RBC (r= 0.17, p< 0.001), plasma hemoglobin concentrations (r= 0.14, p< 0.001), hematocrit value (r= 0.15, p< 0.001) and WBC (r= 0.17, p< 0.01). Subjects in the upper quartile of IR had higher levels of plasma glucose, fasting insulin, triglycerides, hematocrit, hemoglobin, RBC and WBC count than those in the lower quartile. In conclusion, IR seems to be associated with alterations in several hematological parameters. These hematological alterations may be considered an indirect feature of the IR syndrome.

References

Feb 1, 1983·British Journal of Haematology·A KurtzC Bauer
Dec 1, 1982·The Journal of Clinical Endocrinology and Metabolism·N BerschD W Golde
Jan 1, 1997·British Journal of Haematology·G D LoweF G Fowkes
May 22, 2003·Diabetes Research and Clinical Practice·K M ChoiUNKNOWN Koreans-Southwest Seoul (SWS) Study
Oct 18, 2003·Metabolism: Clinical and Experimental·Ataru TaniguchiYoshikatsu Nakai
Apr 9, 2004·The New England Journal of Medicine·John DaneshVilmundur Gudnason

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Citations

Sep 28, 2012·Diabetes & Metabolic Syndrome·Kelsey NebeckMichelle A Williams
Dec 6, 2014·Cell Biochemistry and Biophysics·Xuekui LiuLu Qi
Jul 9, 2016·Journal of Physical Therapy Science·Cenk AypakMine Araz
Jun 18, 2019·Diabetes/metabolism Research and Reviews·Daniela FerreiraElisabete Ramos
Oct 28, 2019·Animal : an International Journal of Animal Bioscience·B L HollemaS Hermesch
Dec 14, 2018·Lipids in Health and Disease·Samuel Antwi-BaffourMahmood Abdulai Seidu
Aug 9, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Jianghua WenFang Hu

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