PMID: 9654258Jul 8, 1998Paper

Relation between laboratory test results and histological hepatitis activity in individuals positive for hepatitis B surface antigen and antibodies to hepatitis B e antigen

Lancet
F ter BorgE A Jones

Abstract

Hepatitis B surface antigen (HBsAg) and antibodies to hepatitis B e antigen (anti-HBe) commonly coexist, and laboratory tests are often requested to assess histological hepatitis activity. An optimum panel of tests has not been found and the usefulness of hepatitis B virus (HBV) DNA assays in this context has not been established. We assessed various blood tests to find which best predicted hepatitis activity. Routine plasma biochemical liver tests and serum HBV DNA (hybridisation and PCR assays) were assessed prospectively in 123 patients positive for HBsAg and anti-HBe. We scored histological hepatitis activity (hepatitis activity index) and determined whether chronic active hepatitis (chronic hepatitis with portal and periportal lesions) was present. We analysed the relation between laboratory data and the hepatitis activity index or risk of chronic active hepatitis by multiple regression and multiple logistic regression, respectively. The analyses provided models for predicting either the hepatitis activity index or the risk of chronic active hepatitis. Aspartate aminotransferase was the most important test in the two models. The contribution of HBV DNA and other assays, especially alanine-aminotransferase activity, were of...Continue Reading

References

May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y F LiawT J Chen
Feb 1, 1987·Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences·W L ChuangT Y Chow
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J McCulloughA J Czaja
Mar 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B DragosicsH Denk
Mar 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G FattovichG Realdi
Nov 1, 1984·Annals of Internal Medicine·J I WeissbergP B Gregory
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jul 1, 1994·Antiviral Research·A Alberti, G Fattovich
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Nov 1, 1993·Demography·S H Preston
Feb 1, 1993·Annals of Internal Medicine·R de FranchisG Ronchi

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Citations

Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Samuel H SigalSwan N Thung
Sep 14, 2001·Journal of Viral Hepatitis·G V Papatheodoridis, S J Hadziyannis
Oct 26, 2005·Journal of Gastroenterology and Hepatology·Ping-Nam WongAndrew Km Wong
May 22, 2009·Journal of Gastroenterology and Hepatology·Grace L-H WongHenry L-Y Chan
Oct 9, 2003·Journal of Clinical Microbiology·Henry Lik-Yuen ChanJoseph Jao-Yiu Sung
Aug 29, 2000·Journal of Clinical Pathology·F ter BorgE A Jones
Nov 10, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·P SellierC Lafuente-Lafuente
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Jae Y CheongSung W Cho
Nov 20, 1998·Lancet·F ter Borg, E A Jones
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordan J FeldE Jenny Heathcote
Aug 16, 2000·The Journal of Infection·M WrightH C Thomas
Jun 30, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Pierre-Emmanuel RautouDominique Valla
Jan 11, 2001·The American Journal of Gastroenterology·H L ChanJ J Sung
Feb 7, 2002·Hospital Medicine·Henry Lik-Yuen Chan
Mar 19, 2009·The American Journal of Gastroenterology·Abdel-Rahman El-ZayadiKhaled Zalata
Jun 11, 2003·Neonatal Network : NN·Debbie Fraser Askin, William L Diehl-Jones
Mar 14, 2003·The Pediatric Infectious Disease Journal·Corina HartmanRaanan Shamir
Sep 28, 2002·Transplantation·Edward Gane, Helen Pilmore
Oct 14, 2017·Scientific Reports·Sangshin Park, Nam-Kyong Choi

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