PMID: 11922893Apr 2, 2002Paper

Relation between local myocardial growth and blood flow during chronic ventricular pacing

Cardiovascular Research
M F van OosterhoutF W Prinzen

Abstract

Several studies have shown that, per unit mass, myocardial blood flow (MBF) and oxygen consumption are similar in hypertrophic and non-hypertrophic ventricles. This observation may be explained by the degree of myocardial growth matching the increase in oxygen demand. Such matching may, however, not be perfect at the local level, because substantial heterogeneity of MBF exists within the ventricular wall. We investigated to what extent local growth and MBF are matched after redistribution of workload within the left ventricular (LV) wall. Redistribution of workload was established by ventricular pacing at physiological heart rate, which induces asynchronous activation and contraction. Local wall mass (2D-echocardiography) and MBF (fluorescent microspheres) were determined in the canine LV wall before (t=0) and after 6 months of normal sinus rhythm (SHAM group, n=5) or 6 months of pacing at the LV free wall (PACE group, n=8). During acute pacing MBF (ml/min/g) increased with increasing distance to the pacing site. Local relative MBF (rMBF, local MBF normalized to mean MBF in the LV wall) varied from 0.8 adjacent to the pacing site to 1.2 in remote regions. After 6 months of pacing these regional differences had disappeared, prob...Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J SadoshimaS Izumo
Apr 1, 1990·European Heart Journal·P AnversaG Olivetti
Nov 1, 1990·Basic Research in Cardiology·P M ScholzH R Weiss
May 1, 1990·Circulation Research·J B BassingthwaighteK A Krohn
Jan 1, 1989·Pflügers Archiv : European journal of physiology·L H SnoeckxR S Reneman
May 1, 1985·The Journal of Clinical Investigation·G CooperT A Marino
Aug 1, 1985·Circulation Research·R B KingL B Rowell
Mar 15, 1997·Journal of the American College of Cardiology·H F Tse, C P Lau
Nov 5, 1997·Pflügers Archiv : European journal of physiology·J BussemakerJ H van Beek
Nov 17, 1998·Pflügers Archiv : European journal of physiology·R LoncarA Deussen
Jan 8, 1999·Basic Research in Cardiology·A Deussen
Mar 7, 2001·Cardiovascular Research·M F van OosterhoutF W Prinzen
Apr 11, 2001·Pflügers Archiv : European journal of physiology·U K DeckingJ Schrader

❮ Previous
Next ❯

Citations

Aug 24, 2012·Annals of Biomedical Engineering·James B BassingthwaighteKalyan Vinnakota
Nov 26, 2010·Heart Failure Reviews·Frits W PrinzenTammo Delhaas
Dec 7, 2011·Nature Reviews. Cardiology·Norimichi Koitabashi, David A Kass
Nov 1, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Roy C P KerckhoffsAndrew D McCulloch
Jun 3, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi AshikagaJames W Covell
Dec 2, 2011·Journal of Cardiovascular Translational Research·Marc StrikKevin Vernooy
Nov 26, 2010·Heart Failure Reviews·Irene E van GeldorpTammo Delhaas
Feb 16, 2010·The American Journal of Cardiology·John RickardBruce L Wilkoff
Sep 9, 2008·Progress in Cardiovascular Diseases·Chung-Wah SiuHung-Fat Tse
Jun 19, 2007·The Journal of Surgical Research·D Dean PotterThoralf M Sundt
Aug 12, 2005·Annals of the New York Academy of Sciences·James B BassingthwaighteHong Qian
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mirza Faisal BegRaimond L Winslow
Apr 1, 2008·Annals of the New York Academy of Sciences·James B Bassingthwaighte
Mar 21, 2012·Journal of Cardiovascular Electrophysiology·Alice HorovitzJean-Benoit Thambo
Apr 1, 2006·Proceedings of the IEEE·James B BassingthwaighteLes E Atlas
Jul 27, 2006·Progress in Cardiovascular Diseases·David D Spragg, David A Kass
May 1, 2007·Journal of the American College of Cardiology·Ward Y VanagtFrits W Prinzen
Jul 28, 2012·Progress in Biophysics and Molecular Biology·Evelien HermelingNico H L Kuijpers
May 11, 2007·Expert Review of Cardiovascular Therapy·James O Mudd, David A Kass
Jul 10, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Mariola SzulikJens-Uwe Voigt
Aug 20, 2003·Circulation·David D SpraggDavid A Kass
Apr 27, 2019·Circulation. Arrhythmia and Electrophysiology·Jürgen DuchenneJens-Uwe Voigt
Dec 24, 2004·European Heart Journal·Kevin VernooyFrits W Prinzen
Nov 22, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Tada YipintsoiJames B Bassingthwaighte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.