PMID: 6538385Apr 1, 1984Paper

Relation between marked changes in left ventricular outflow tract gradient and disease progression in hypertrophic cardiomyopathy

The American Journal of Cardiology
E CiróS E Epstein

Abstract

Spontaneous and persistent changes in left ventricular (LV) outflow gradient have been observed occasionally in patients with hypertrophic cardiomyopathy (HC). However, the significance and frequency of such hemodynamic alterations have not been established. In this study, the serial preoperative hemodynamic status of 409 patients with HC was analyzed. Basal LV outflow tract obstruction either spontaneously appeared (or increased) or disappeared (or decreased) in 19 nonoperated patients (about 5%). Changes in hemodynamic state were shown by serial cardiac catheterization in 17 patients and by catheterization and M-mode echocardiography in 2 patients. In most patients (12 of 19), subaortic obstruction under basal conditions appeared or increased; 8 became more symptomatic and in 4 the condition remained stable. Reduction or loss of LV outflow gradient occurred in 7 patients; in 5 of these the condition deteriorated clinically and in 2 it did not change. Hence, in 13 of the 19 patients (70%), spontaneous changes in the magnitude of the basal LV outflow gradient were associated with symptomatic progression. The mechanism of the decrease or disappearance of subaortic obstruction in those patients who deteriorated clinically appeare...Continue Reading

References

Jan 1, 1976·Circulation·B J MaronS E Epstein
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Citations

Aug 1, 1993·Journal of the American College of Cardiology·G M HechtB J Maron
Aug 26, 1998·The American Journal of Cardiology·M HorimotoM Sekiguchi
May 1, 1985·Journal of the American College of Cardiology·H NewmanW J McKenna
Nov 1, 1996·Journal of the American College of Cardiology·K NishigakiH Fujiwara
Jan 5, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·K YamajiS Nakamura
Dec 1, 2011·Acta Informatica Medica : AIM : Journal of the Society for Medical Informatics of Bosnia & Herzegovina : časopis Društva Za Medicinsku Informatiku BiH·Ramush A BejiqiHana Sh Bejiqi
Jul 1, 1985·Progress in Cardiovascular Diseases·E D WigleW G Williams
Sep 21, 2010·International Journal of Cardiology·Georgios K EfthimiadisGeorgios E Parcharidis
Oct 1, 1995·Circulation·E D WigleW G Williams
Mar 1, 1992·Pediatric Annals·T W Rowland
Apr 2, 1987·The New England Journal of Medicine·B J MaronS E Epstein
May 1, 2021·Journal of Clinical Medicine·Beatrice MusumeciCamillo Autore

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