Relation between patterns of intrinsic network connectivity, cognitive functioning, and symptom presentation in trauma-exposed patients with major depressive disorder

Brain and Behavior
Melissa ParlarMargaret C McKinnon

Abstract

The present study investigated resting fMRI connectivity within the default mode (DMN), salience (SN), and central executive (CEN) networks in relation to neurocognitive performance and symptom severity in trauma-exposed patients with major depressive disorder (MDD). Group independent component analysis was conducted among patients with MDD (n = 21), examining DMN, SN, and CEN connectivity in relation to neurocognitive performance and symptom severity. Activation in these networks was also compared between the patient group and healthy controls (n = 20). Among the patient group, higher levels of performance on measures of verbal memory and executive functioning were related to increased connectivity within the DMN (i.e., inferior parietal lobe; precuneus). Greater depression severity was related to reduced connectivity between the SN and a node of the DMN (i.e., posterior cingulate cortex) and higher depersonalization symptoms were related to enhanced connectivity between the SN and a node of the DMN (i.e., middle temporal gyrus). Higher symptoms of depersonalization were also associated with reduced integration of the DMN with the medial frontal gyrus. Relative to controls, patients with MDD showed greater connectivity of the ...Continue Reading

References

Jun 1, 1989·Neurology·O DevinskyW H Theodore
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
Apr 1, 1965·The British Journal of Psychiatry : the Journal of Mental Science·J C KENNA, G SEDMAN
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Dec 6, 2003·Psychiatry Research·W Vaughn McCall, Aaron G Dunn
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Mar 28, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kaan YucelGlenda M MacQueen
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Oct 1, 2008·Neuroscience and Biobehavioral Reviews·Samantha J BroydEdmund J S Sonuga-Barke
Dec 2, 2008·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Almudena Molina-SerranoMara Barreto
Jan 8, 2009·Journal of Clinical Pharmacy and Therapeutics·J L TongS D Xiao
Mar 3, 2009·Journal of Clinical Pharmacy and Therapeutics·P BedouchJ Calop
May 12, 2009·Journal of Affective Disorders·Lisa M McDermott, Klaus P Ebmeier
Nov 6, 2009·Journal of Neurophysiology·Koene R A Van DijkRandy L Buckner
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Angela R LairdPeter T Fox
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yvette I ShelineMark A Mintun
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Judith K DanielsRuth A Lanius
Oct 14, 2010·Frontiers in Systems Neuroscience·Ilya M VeerSerge A R B Rombouts
Oct 23, 2010·Journal of Psychiatry & Neuroscience : JPN·Judith K DanielsRuth A Lanius
Dec 17, 2010·Human Brain Mapping·Erik Barry ErhardtVince D Calhoun
Dec 28, 2010·Journal of Affective Disorders·Cédric LemognePhilippe Fossati
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Mar 20, 2012·Journal of Affective Disorders·George S AlexopoulosFaith M Gunning
Mar 21, 2012·Journal of Consulting and Clinical Psychology·Kate L HarknessSidney H Kennedy

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Citations

Oct 20, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Haosu ZhangSandro M Krieg
Dec 11, 2019·Anxiety, Stress, and Coping·Regina Marie MusicaroSusan Andersen
Dec 4, 2020·Neuroscience and Biobehavioral Reviews·Monika I Roydeva, Antje A T S Reinders

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Key Resources (RRID) Mentioned

SCR_007037
SCR_001953
SCR_014757

Software Mentioned

GIFT
Artifact Detection Tool ( ART )
SPM8
SPSS
Mindstreams
MATLAB
Group ICA of fMRI Toolbox ( GIFT )
ART
GROUPICAT

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