PMID: 8946663Dec 1, 1996Paper

Relation between plasma and saliva concentrations of enoxacin, ciprofloxacin, and theophylline

Therapeutic Drug Monitoring
S ZhaiR E Vestal

Abstract

To assess the reliability of predicting plasma concentrations of enoxacin, ciprofloxacin, and theophylline from drug concentrations in saliva, six healthy volunteers received single oral doses of enoxacin, ciprofloxacin, and theophylline administered in combination on each of four separate study days, with different, doses separated by at least 5 days. Drug concentrations were determined by a newly developed high-performance liquid chromatography (HPLC) assay, which could measure simultaneously all three drugs in plasma or saliva. Saliva data from the postabsorptive phase after drug administration were used to minimize the effects of variation in absorption. There were good correlations between saliva and plasma concentrations of enoxacin, ciprofloxacin, and theophylline (r = 0.91, 0.88, and 0.98, respectively). The mean (+/-SD) saliva-to-plasma (S/P) ratio for theophylline was 0.63 +/- 0.06 with a coefficient of variation (CV) of 7.9 +/- 2.7%. In contrast, the S/P ratios and CV values for enoxacin and ciprofloxacin were 0.72 +/- 0.21 and 28.9 +/- 11.1%, and 0.58 +/- 0.15 and 25.3 +/- 6.7%, respectively. Because of the large inter- and intraindividual variability, saliva concentrations of enoxacin and ciprofloxacin are not reli...Continue Reading

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Citations

Nov 19, 2002·Antimicrobial Agents and Chemotherapy·Martin BrunnerMarkus Müller
Jan 10, 2002·Journal of Pharmaceutical Sciences·Patrick Poulin, Frank-Peter Theil
Mar 31, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Gregory VenetisIoannis P Kioumis
May 21, 2003·Human & Experimental Toxicology·Mohammad AbdollahiAmir A Yaaghoubi
May 21, 2005·Therapeutic Drug Monitoring·Amanda J JenkinsEdward J Cone

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