Relation between preoperative inspiratory lung resistance and the outcome of lung-volume-reduction surgery for emphysema

The New England Journal of Medicine
E P IngenitoJ J Reilly

Abstract

Surgery to reduce lung volume has recently been reintroduced to alleviate dyspnea and improve exercise tolerance in selected patients with emphysema. A reliable means of identifying patients who are likely to benefit from this surgery is needed. We measured lung resistance during inspiration, static recoil pressure at total lung capacity, static lung compliance, expiratory flow rates, and lung volumes in 29 patients with chronic obstructive lung disease before lung-volume-reduction surgery. The changes in the forced expiratory volume in one second (FEV1) six months after surgery were related to the preoperatively determined physiologic measures. A response to surgery was defined as an increase in the FEV1 of at least 0.2 liter and of at least 12 percent above base-line values. Of the 29 patients, 23 had some improvement in FEV1 including 15 who met the criteria for a response to surgery. Among the variables considered, only preoperative lung resistance during inspiration predicted changes in expiratory flow rates after surgery. Inspiratory lung resistance correlated significantly and inversely with improvement in FEV1 after surgery (r=-0.63, P<0.001). A preoperative criterion of an inspiratory resistance of 10 cm of water per l...Continue Reading

References

Jun 1, 1968·The Journal of Clinical Investigation·G GrimbyJ Mead
Sep 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R BrownR H Ingram
Sep 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J NagelsK P Van de Woestijne
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·S E LapinskyA S Slutsky
Jan 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·J D CooperC L Roper
Apr 25, 1996·The New England Journal of Medicine·F C SciurbaR J Landreneau
Jul 1, 1996·Chest·M BrennerS S Lefrak
Oct 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·R BingisserW Weder
Jul 1, 1997·Journal of the American College of Surgeons·S J SwansonD J Sugarbaker
Jan 1, 1964·Journal of Applied Physiology·E SALAZAR, J H KNOWLES
Jul 1, 1955·The Journal of Clinical Investigation·J MEADE A GAENSLER

❮ Previous
Next ❯

Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Francis C Cordova, Gerard J Criner
Mar 12, 2004·The Journal of Surgical Research·Keith S Naunheim
Sep 27, 2001·Anesthesiology Clinics of North America·E M Tschernko
Jun 27, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Katherine P Grichnik, Steven E Hill
Nov 24, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M L MoyJ J Reilly
Jul 27, 2000·The New England Journal of Medicine·P J Barnes
Sep 24, 2010·The New England Journal of Medicine·Frank C SciurbaUNKNOWN VENT Study Research Group
Aug 19, 1999·Thorax·D M Geddes
Apr 11, 2009·Journal of Applied Physiology·Stephen H LoringAtul Malhotra
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·H E Fessler, R A Wise
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·E P IngenitoJ J Reilly
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·E P IngenitoA Hoffman
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Henry E FesslerSolbert Permutt
Dec 8, 2009·American Journal of Respiratory and Critical Care Medicine·George R WashkoUNKNOWN National Emphysema Treatment Trial Research Group
May 6, 2008·Proceedings of the American Thoracic Society·Edward P IngenitoJames P Utz
May 6, 2008·Proceedings of the American Thoracic Society·Victor KimGerard J Criner
May 6, 2008·Proceedings of the American Thoracic Society·Malcolm M DeCampMark J Krasna
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Gaëlle DauriatMichel Fournier
Apr 3, 2012·European Radiology·Matthew S BrownJonathan G Goldin
Mar 26, 2003·Seminars in Thoracic and Cardiovascular Surgery·Konrad E BlochWalter Weder
May 6, 2008·Proceedings of the American Thoracic Society·Henry E FesslerAmir Sharafkhaneh
Oct 24, 2012·Anesthesiology Clinics·Marcos F Vidal MeloDavid W Kaczka
Jan 5, 2000·Chest·S J Mentzer, S J Swanson
Sep 18, 2007·Seminars in Thoracic and Cardiovascular Surgery·Steven J Mentzer
Jun 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Stephen H LoringJohn J Reilly
Dec 11, 2002·The Surgical Clinics of North America·Keith S Naunheim
Aug 23, 2001·The Annals of Thoracic Surgery·D E Wood, M M DeCamp
Jan 26, 2010·Respiratory Medicine·Sonia KhiraniAndrea Rossi
Apr 18, 2017·Respiratory Medicine Case Reports·Morgane FaureAri Chaouat
Aug 26, 2009·Journal of Thoracic Imaging·Victor Kim, Robert M Steiner
Apr 6, 2005·Medicine and Science in Sports and Exercise·Melissa R MazanAndrew Hoffman
Jun 1, 2000·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·K R FlahertyF J Martinez
Mar 31, 2000·Current Opinion in Pulmonary Medicine·K C MeyerR B Love
Jan 26, 2016·Current Opinion in Pulmonary Medicine·Gianluca MilaneseNicola Sverzellati
Oct 4, 2006·Current Opinion in Anaesthesiology·A ZollingerT Pasch
Dec 24, 2010·American Journal of Respiratory and Critical Care Medicine·Stacy RavivRavi Kalhan
Jan 23, 1999·Anesthesia and Analgesia·E M TschernkoW Haider

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
K L Anderson
The Cochrane Database of Systematic Reviews
M J HensleyP G Gibson
The Cochrane Database of Systematic Reviews
L U TiongB Smith
© 2022 Meta ULC. All rights reserved