PMID: 7536717Apr 1, 1995Paper

Relation between pressure natriuresis and urinary excretion of nitrate/nitrite in anesthetized dogs

Hypertension
D S MajidL G Navar

Abstract

Alterations in intrarenal nitric oxide (NO) formation during changes in renal arterial pressure (RAP) have been suggested as a mechanism mediating pressure natriuresis. To test this hypothesis further, we examined the relation between RAP and the urinary excretion rate of nitrate/nitrite (NO3-/NO2-; NO metabolites) in anesthetized sodium-replete dogs before (n = 9) and during (n = 6) intrarenal infusion of the NO synthesis inhibitor nitro-L-arginine (NLA; 50 micrograms.kg-1.min-1). Urinary NO3-/NO2- concentrations were measured with the Griess reaction and spectrophotometry methods after enzymatic reduction of NO3- to NO2- in the samples. During control conditions, there were decreases in the urinary NO3-/NO2- excretion rate in response to reductions in RAP (150 to 75 mm Hg; slope, 0.04 +/- 0.01 nmol.min-1.g-1.mm Hg-1) in association with decreases in urinary sodium excretion (UNaV). There was a positive correlation between changes in NO3-/NO2- excretion rate and changes in RAP (r = .48; P < .005) or UNaV (r = .59; P < .001). NLA infusion resulted in decreases in NO3-/NO2- excretion rate (4.8 +/- 1.4 to 1.0 +/- 0.3 nmol.min-1.g-1) in association with reductions in UNaV (4.3 +/- 0.3 to 0.7 +/- 0.2 microL.min-1.g-1), fractional e...Continue Reading

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Citations

Jan 10, 2002·European Journal of Pharmacology·M RahmaY Abe
Apr 18, 1997·European Journal of Pharmacology·Y AdachiS Satoh
May 4, 1999·Clinical and Experimental Pharmacology & Physiology·R KomersL Kazdová
Mar 12, 2004·Nephrology·Hirobumi TokuyamaTakao Saruta
Aug 1, 1997·Clinical and Experimental Pharmacology & Physiology·D S Majid, L G Navar
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Roger G EvansGabriela A Eppel
Nov 1, 1996·British Journal of Pharmacology·E NavaF J Salazar
Jul 27, 2006·Acta Physiologica·P F Mount, D A Power
Jul 1, 1997·Kidney International·S AielloG Remuzzi
Feb 24, 2006·Neurourology and Urodynamics·Ho-Shiang HuangJun Chen
Dec 11, 1999·Proceedings of the Association of American Physicians·M Noris, G Remuzzi
Apr 1, 1997·Hypertension·D S MajidL G Navar
Apr 14, 2017·American Journal of Physiology. Renal Physiology·Martha FrancoL Gabriel Navar
Mar 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elisabete A Dos SantosRichard J Roman
Aug 5, 1998·The American Journal of Physiology·M Godfrey, D S Majid
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Dec 31, 1997·The American Journal of Physiology·M I MadridF J Fenoy
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·M FrancoJ Herrera-Acosta
Oct 6, 1997·The Medical Clinics of North America·L G Navar
Oct 20, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·H M H van EijkN E P Deutz

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