Relation between reflux of bile acids into the stomach and gastric mucosal atrophy, intestinal metaplasia in biopsy specimens.

Journal of Clinical Biochemistry and Nutrition
Takeshi Matsuhisa, Taku Tsukui

Abstract

During endoscopic examinations we collected fluid in the stomach that included reflux fluid from the duodenum, and assessed the effect of quantitatively determined bile acids on glandular atrophy and intestinal metaplasia using biopsy specimens. A total of 294 outpatients were enrolled in this study. Total bile acid concentration was measured by an enzyme immunoassay. Glandular atrophy and intestinal metaplasia scores were graded according to the Updated Sydney System. An effect of refluxed bile acids on atrophy and intestinal metaplasia was shown in the high-concentration reflux group in comparison with the control group. However, when the odds ratios (ORs) were calculated according to whether Helicobacter pylori (H. pylori) infection was present, no significant associations were shown between reflux bile acids and atrophy in either the H. pylori-positive cases or -negative cases. The same was true for intestinal metaplasia in the H. pylori-positive cases, whereas intestinal metaplasia was more pronounced in the high-concentration reflux group in the H. pylori-negative cases (OR 2.4, 95%CI 1.1-5.6). We could not clarify the effect of the reflux of bile acids into the stomach in the progression of atrophy. High-concentration bi...Continue Reading

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Citations

Mar 26, 2013·Journal of Clinical Biochemistry and Nutrition·Kenro HirataToshifumi Hibi
Aug 9, 2016·Journal of Clinical Biochemistry and Nutrition·Noriko NakajimaNoriko Kinukawa
Nov 11, 2016·Journal of Cancer Research and Clinical Oncology·Jian-Xia JiangShun-Fu Xu
Feb 1, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Takeshi MatsuhisaKen Haruma
Jun 27, 2015·European Journal of Gastroenterology & Hepatology·Jan Bornschein

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Methods Mentioned

BETA
biopsy
biopsies

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