Relation between resting sympathetic outflow and vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Austin T RobinsonWilliam B Farquhar

Abstract

Previous studies have demonstrated an inverse relation between resting muscle sympathetic nerve activity (MSNA) and vasoconstrictor responsiveness (i.e., sympathetic transduction), such that those with high resting MSNA have low vascular responsiveness, and vice versa. The purpose of this investigation was to determine whether biological sex influences the balance between resting MSNA and beat-to-beat sympathetic transduction. We measured blood pressure (BP) and MSNA during supine rest in 54 healthy young adults (27 females: 23 ± 4 yr, 107 ± 8/63 ± 8 mmHg; 27 males: 25 ± 3 yr, 115 ± 11/64 ± 7 mmHg; means ± SD). We quantified beat-to-beat fluctuations in mean arterial pressure (MAP, mmHg) and limb vascular conductance (LVC, %) for 10 cardiac cycles after each MSNA burst using signal averaging, an index of sympathetic vascular transduction. In females, there was no correlation between resting MSNA (burst incidence; burst/100 heartbeats) and peak ΔMAP (r = -0.10, P = 0.62) or peak ΔLVC (r = -0.12, P = 0.63). In males, MSNA was related to peak ΔMAP (r = -0.50, P = 0.01) and peak ΔLVC (r = 0.49, P = 0.03); those with higher resting MSNA had blunted increases in MAP and reductions in LVC in response to a burst of MSNA. In a sub-analy...Continue Reading

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Citations

Nov 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sarah L HissenChloe E Taylor
Oct 17, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph C WatsoWilliam B Farquhar
Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Rachel E EngellandSteven A Romero
Aug 1, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Ryosuke TakedaQi Fu
Aug 1, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Yasmine CoovadiaCharlotte W Usselman
Sep 1, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Sarah L Hissen, Chloe E Taylor
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Oct 10, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Myles W O'BrienDerek S Kimmerly
Jan 9, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Benjamin E YoungPaul J Fadel
Sep 24, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dain W JacobJacqueline K Limberg
Nov 16, 2020·The Journal of Clinical Hypertension·Chin-Chou HuangJaw-Wen Chen
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Jul 22, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Massimo NardonePhilip J Millar
Sep 11, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Massimo NardonePhilip J Millar

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Datasets Mentioned

BETA
GM113125

Clinical Trials Mentioned

NCT02881515
NCT03560869

Software Mentioned

LabVIEW
SPSS
GraphPad Prism
Nutrient Data System for Research ( NDSR

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