PMID: 240676Mar 3, 1975Paper

Relation between structure and function in some partially synthetic ribonucleases S'. Enzymic and spectroscopic investigation on [Orn10, Asn14]-RNase S' and 1epsilon, 7epsilon, 10delta-triguanidino-[Orn10, Asn14]-RNase S'

European Journal of Biochemistry
B FilippiF Marchiori


Some analogues have been prepared of S-peptide, the peptide obtained together with S-protein from subtilisn-modified beef pancreatic R Nase A. The syntheses are described of [Orn10, Asn14]-S-peptide and 1epsilon, 7epsilon, 10delta-triguanidino-[Orn10, Asn14]-S-peptide. The S-peptide analogues are able to activate S-protein at the level of the parent [Orn10]-S-peptide and 1epsilon, 7epsilon-diguanidino-S-peptide respectively, although at high peptide-to-protein molar ratios. After their recombination with S-protein the buried character of Tyr-25 was restored, as judged from difference absorption and circular dichroism spectra in the near-ultraviolet region. These findings indicate that the asparaginyl residue is a possible naturally occurring substituent in the R Nase A sequences whose state of amidation in position 14 has not yet been defined.


Jan 1, 1968·Advances in Protein Chemistry·G G Hammes
Oct 26, 1971·Biochemistry·D S Fung, M S Doscher
May 6, 1970·Journal of the American Chemical Society·K HofmannF M Finn
Mar 4, 1967·Nature·G KarthaD Harker
Oct 1, 1968·FEBS Letters·A M. TamburroE Scoffone
Sep 1, 1952·The Biochemical Journal·D SHUGAR
Feb 5, 1965·Journal of the American Chemical Society·F M FINN, K HOFMANN
Feb 1, 1958·Proceedings of the National Academy of Sciences of the United States of America·F M Richards

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Mar 1, 1993·Protein Science : a Publication of the Protein Society·J S Kim, R T Raines
Sep 20, 1977·Biochemistry·A A Schreier, R L Baldwin
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