Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients

International Journal of Chronic Obstructive Pulmonary Disease
Renata FerrariIrma Godoy

Abstract

The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV1] =54%±23%) were evaluated. We evaluated serum concentrations of IL-8, CRP, and TNF-α. Peripheral muscle mass was evaluated by computerized tomography (CT); midthigh cross-sectional muscle area (MTCSA) and midarm cross-sectional muscle area (MACSA) were obtained. Quadriceps, triceps, and biceps strength were assessed through the determination of the one-repetition maximum. The multiple regression results, adjusted for age, sex, and FEV1%, showed positive significant association between MTCSA and leg extension (0.35 [0.16, 0.55]; P=0.001), between MACSA and triceps pulley (0.45 [0.31, 0.58]; P=0.001), and between MACSA and biceps curl (0.34 [0.22, 0.47]; P=0.001). Plasma TNF-α was negatively associated with leg extension (-3.09 [-5.99, -0.18]; P=0.04) and triceps pulley (-1.31 [-2.35, -0.28]; P=0.01), while plasma CRP presented negative association with biceps curl (-0.06 [-0.11, -0.01]; P=0.02). Our results showed negative association betwee...Continue Reading

Citations

Dec 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Alice S RyanFrederick M Ivey
Nov 7, 2017·Clinical Physiology and Functional Imaging·Isabelle VivodtzevJean-Louis Pépin
Oct 26, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yanfei BinZhi-Yi He
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Aug 8, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yeonsil MoonSeol-Heui Han
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May 15, 2019·Journal of Clinical Medicine·Eun Kyung ChoeJoo Sung Kim
Jul 31, 2018·Rehabilitation Research and Practice·Vanessa K S LageVanessa A Mendonça
Nov 30, 2019·Frontiers in Physiology·Ren-Jay SheiStefanie Krick
Nov 24, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Juliana Souza UzelotoErcy Mara Cipulo Ramos

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Methods Mentioned

BETA
enzyme linked immunosorbent assay

Software Mentioned

STATA

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