Relation of 99mTc-sestamibi washout with myocardial properties in patients with hypertrophic cardiomyopathy.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Satoshi IsobeToyoaki Murohara

Abstract

We sought to determine the relationship between (99m)Tc-sestamibi washout and myocardial properties in hypertrophic cardiomyopathy (HCM) patients. Twenty-four HCM patients underwent biventricular cardiac catheterization, with a micromanometer-tipped catheter, both at rest and during atrial pacing, echocardiography and myocardial (99m)Tc-sestamibi scintigraphy at rest. The (99m)Tc-sestamibi washout rate (WR) was calculated using initial and delayed planar images. The HCM patients were divided into two groups as follows: Group A consisted of 13 patients showing (99m)Tc-sestamibi WR < 22.5%; group B of 11 patients showing (99m)Tc-sestamibi WR ≥ 22.5%. Significant correlations were observed between (99m)Tc-sestamibi WR and percentage changes in pressure half-time (T (1/2)), as well as those in the maximum first derivative LV pressure (LV dP/dt (max)) (r = .43, P = .033; r = -.63, P = .001). The percentage changes in LV dP/dt (max) and those in T (1/2) were significantly more reduced in group B than in group A (P < .05). The biphasic force-frequency relation was more frequently observed in group B than in group A (82% vs. 18%). Increased (99m)Tc-sestamibi washout is associated with an impaired contractile reserve and prolonged relax...Continue Reading

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Citations

Jan 25, 2013·Annals of Nuclear Medicine·Tsubasa WatanabeMasahiro Hiraoka
Jun 19, 2015·International Heart Journal·Masataka YoshinagaHideo Izawa
May 24, 2015·Cardiac Electrophysiology Clinics·David Montaigne, Anju Duva Pentiah
Mar 19, 2013·Journal of the American College of Cardiology·H William Strauss
Feb 9, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Naoaki KanoToyoaki Murohara

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