Relation of albuminuria to left ventricular mass (from the HyperGEN Study)

The American Journal of Cardiology
Luc DjousseR B Devereux

Abstract

Although albuminuria has been associated with a larger left ventricular (LV) mass in hypertensive and diabetic populations, little is known about this association in normotensive adults. We hypothesized that albuminuria is positively associated with LV mass in normotensive and hypertensive subjects. We analyzed data from 3,445 participants of the Hypertension Genetic Epidemiology Network (HyperGEN) Study (mean age 48.6 +/- 13.7 years, range 18 to 87, 57% women). LV parameters were obtained by echocardiography. Urinary albumin was estimated using standard methods. From the lowest to highest quartile of albuminuria, multivariable adjusted means of LV mass indexed to body surface area were 71.9, 73.3, 74.0, and 76.5 g/m2, respectively (p for trend = 0.002) in normotensive participants. Corresponding values for hypertensive subjects were 87.4, 89.3, 92.3, and 94.9 g/m2, respectively (p for trend <0.0001). Similar results were observed for LV mass indexed to height2.7. In secondary analyses, we found similar associations for men and women and after exclusion of subjects with diabetes. Furthermore, positive associations were observed between albuminuria and LV wall thickness in hypertensive and normotensive subjects. Albuminuria was ...Continue Reading

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Citations

Oct 6, 2014·JACC. Heart Failure·Jalal K Ghali
Mar 25, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kumar NarayananSumeet S Chugh
Feb 12, 2015·Journal of the American Society of Hypertension : JASH·Rudolph SchutteAletta E Schutte
Sep 5, 2009·American Journal of Hypertension·Ausilia MaioneGiovanni Strippoli
Apr 26, 2017·The American Journal of Cardiology·David B HannaJorge R Kizer
Oct 14, 2017·European Heart Journal Cardiovascular Imaging·Peter Godsk JørgensenJan Skov Jensen
Mar 7, 2021·International Urology and Nephrology·Zhibin HongLi Zhang

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