Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women

The New England Journal of Medicine
A G UitterlindenStuart H Ralston

Abstract

Osteoporosis is a common disorder with a strong genetic component. One way in which the genetic component could be expressed is through polymorphism of COLIA1, the gene for collagen type Ialpha1, a bone-matrix protein. We determined the COLIA1 genotypes SS, Ss, and ss in a population-based sample of 1778 postmenopausal women using a polymerase-chain-reaction-based assay. We then related the genotypes to bone mineral density and the occurrence of osteoporotic fractures in these women. As compared with the 1194 women with the SS genotype, the 526 women with the Ss genotype had 2 percent lower bone mineral density at the femoral neck (P=0.003) and the lumbar spine (P=0.02); the 58 women with the ss genotype had reductions of 4 percent at the femoral neck (P= 0.05) and 6 percent at the lumbar spine (P=0.005). These differences increased with age (P=0.01 for modification by age of the effect of COLIA1 on femoral-neck bone density, and P=0.004 for modification of the effect on lumbar-spine bone density). Women with the Ss and ss genotypes were overrepresented among the 111 women who had incident nonvertebral fractures (relative risk per copy of the s allele, 1.5; 95 percent confidence interval, 1.1 to 2.1). The COLIA1 polymorphism is...Continue Reading

References

Jan 1, 1992·Annual Review of Medicine·P H Byers, R D Steiner
Jul 1, 1991·European Journal of Epidemiology·A HofmanF A van den Ouweland
Sep 1, 1989·Annals of Internal Medicine·S L HuiC C Johnston
Mar 2, 1989·The New England Journal of Medicine·E SeemanG Jerums
Dec 1, 1988·Annals of Internal Medicine·R A EvansS Y Wong
Sep 1, 1987·The Journal of Clinical Investigation·N A PocockS Eberl
Nov 1, 1973·The Journal of Clinical Investigation·D M SmithC C Johnston
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A KanisN Khaltaev
Jun 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S B SorokoD Kritz-Silverstein
Jun 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L D SpotilaN Olsen
Oct 20, 1994·The New England Journal of Medicine·E P SmithK S Korach
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A Krall, B Dawson-Hughes
Jan 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J KellyJ Eisman
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R GuéguenG Siest
Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S KobayashiH Orimo
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G S Cooper, D M Umbach
Jun 1, 1997·American Journal of Human Genetics·M L JohnsonR B Recker
Jan 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H BurgerH A Pols

❮ Previous
Next ❯

Citations

Dec 29, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Karine RobertNathalie Janel
Nov 13, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yoshiji YamadaHiroshi Shimokata
Mar 23, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Hong-yan ZhaoJia-lun Chen
Dec 13, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Viguet-CarrinP D Delmas
May 31, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S-F LeiH-W Deng
Jun 10, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P F GiampietroN Ghebranious
Sep 23, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z-M ZhangL-Y Dai
Jun 24, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N González-BofillB L Langdahl
Jun 10, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M O ErdoganE Colak
Aug 28, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H JinS H Ralston
Dec 14, 2004·Calcified Tissue International·Pedro Mezquita-RayaFernando Escobar-Jiménez
Sep 13, 2008·Calcified Tissue International·Gregory J TranahUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Oct 1, 2009·Calcified Tissue International·Bich N H TranTuan V Nguyen
Jul 5, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Danny ChanKenneth M C Cheung
Apr 3, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kuen Tak SuhJung Sub Lee
Mar 12, 2009·Journal of Bone and Mineral Metabolism·Tomohiko UranoSatoshi Inoue
Jul 11, 2006·Wiener medizinische Wochenschrift·Barbara Obermayer-Pietsch
Feb 11, 2010·Molecular Biology Reports·Edith Falcón-RamírezMargarita Valdés-Flores
May 6, 2003·Current Diabetes Reports·Francis VasseurPhilippe Froguel
Sep 12, 2000·Current Gastroenterology Reports·J Heathcote
Nov 22, 2001·Maturitas·F MassartM L Brandi
Oct 17, 2001·Experimental Gerontology·P Huijbers, D L Knook
Sep 13, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Yoshiji YamadaHiroshi Shimokata
Aug 3, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·S G HormuzdiP Bornstein
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·V Gilsanz
Dec 19, 2003·Molecular Genetics and Metabolism·Yoshiji YamadaHiroshi Shimokata

❮ Previous
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