Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation

Bone Marrow Transplantation
A H ElmaagacliD W Beelen

Abstract

Polymorphisms in cytokine genes can influence immune responses and inflammation and thereby affecting the outcome of hematopoietic stem-cell transplantation. We analyzed a single-nucleotide polymorphism in the gene for the interleukin-23 receptor (IL-23R) (1142G>A) in a cohort of 221 transplant recipients and their human leukocyte antigen (HLA)-identical sibling donors and in a second cohort of 186 transplant recipients and their HLA-identical unrelated donors. Genotypes were tested for an association with graft-versus-host disease (GVHD) by multivariate analysis. The donor's IL-23R genotype was significantly associated with a reduced risk of acute GVHD in both cohorts for patients after transplant. Analysis of all 407 transplant recipients showed that IL-23R (1142G>A, Arg381Gln) genotype of the donor was associated with a decreased risk of grades 2-4 acute GVHD (31.6 compared to 51.0%, P=0.02) and grades 3-4 severe acute GVHD (3.9 compared to 23.4%, P=0.003). Death in remission was significantly lower in patients transplanted from donors with variant IL23-R (11.7 versus 27.7%, P=0.028), whereas overall survival or relapse rates were not influenced significantly by the IL-23R genotype. Among recipients of hematopoietic cells fr...Continue Reading

References

Mar 16, 2001·Expert Opinion on Pharmacotherapy·B C McKaig, W A Stack
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christi ParhamKevin W Moore
Jun 23, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Helga-Paula TörökChristian Folwaczny
Nov 13, 2004·The New England Journal of Medicine·Peter J MannonUNKNOWN Anti-IL-12 Crohn's Disease Study Group
Nov 18, 2004·Immunological Reviews·Claire L LangrishDaniel J Cua
Feb 1, 2005·European Journal of Immunology·Serge Vanden EijndenMichel Goldman
Feb 9, 2007·The New England Journal of Medicine·Gerald G KruegerUNKNOWN CNTO 1275 Psoriasis Study Group
Feb 20, 2007·Inflammatory Bowel Diseases·Marla C DubinskyUNKNOWN Western Regional Research Alliance for Pediatric IBD

❮ Previous
Next ❯

Citations

Aug 12, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mohlopheni J MarakalalaGordon D Brown
May 17, 2011·International Journal of Hematology·Tsuyoshi TanabeYasuyuki Fujita
Aug 21, 2013·International Journal of Hematology·Sophie PaczesnyChristy Mumaw
Aug 21, 2013·International Journal of Hematology·Akiyoshi Takami
Feb 22, 2012·Bone Marrow Transplantation·C TingR Abdi
Sep 20, 2011·Current Opinion in Infectious Diseases·Walter J F M van der VeldenJ Peter Donnelly
Aug 20, 2010·Medical Mycology·Cristina CunhaAgostinho Carvalho
Nov 19, 2010·Expert Review of Hematology·Beatriz Martín-AntonioAlvaro Urbano-Ispizua
May 19, 2010·Expert Review of Clinical Immunology·Susan E Conway, Reza Abdi
Sep 20, 2011·Best Practice & Research. Clinical Haematology·Agostinho CarvalhoLuigina Romani
May 11, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Walter J F M van der VeldenNicole M A Blijlevens
Mar 27, 2009·The Journal of Investigative Dermatology·Antonella Di CesareFrank O Nestle
Oct 13, 2015·Inflammatory Bowel Diseases·M Nedim InceMichael J Wannemuehler
Aug 5, 2008·Molecular Immunology·Roelof A de PausEsther van de Vosse
Dec 5, 2012·British Journal of Haematology·Andrew C HarrisJohn E Levine
May 27, 2015·International Journal of Immunogenetics·A M Dickinson, J Norden
Feb 8, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jen-Pi TsaiHorng-Rong Chang
Feb 26, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Anniek B van der WaartHarry Dolstra
Jul 19, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kelly BroenHarry Dolstra
Jan 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jonathan S Serody, Geoffrey R Hill
Jan 29, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ernst Holler
Nov 10, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Bernd GruhnDaniel Steinbach
Jun 15, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Martin WermkeRalf Wassmuth
Jan 11, 2011·Bone Marrow Transplantation·J L EspinozaUNKNOWN Japan Marrow Donor Program
Nov 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph H Chewning, Casey T Weaver
Dec 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yue LiM Nedim Ince
May 30, 2019·Frontiers in Immunology·David BastianXue-Zhong Yu
Jul 22, 2018·Blood Advances·Carolina Martínez-LapercheUNKNOWN GVHD/Immunotherapy Committee of the Spanish Group for Hematopoietic Transplantation
Dec 11, 2020·Expert Review of Hematology·Luisa GiacconeBenedetto Bruno
Sep 4, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alexander KroemerThomas M Fishbein
Oct 17, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Loïc DelensSophie Servais

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