Relation of antimyocardium antibodies to mortality in patients with acute myocardial infarction

Archives of Medical Research
Juan Jesús Sánchez-BarrigaFrancisco Blanco-Favela

Abstract

Antimyocardium antibodies (AMA) have been observed in patients with acute myocardial infarction (AMI). At present it is unknown if these AMA play a role in the pathogenesis of acute or chronic myocardial damage or if they are only produced as a result of tissue destruction, disappearing later without clinical manifestations. However, some studies have shown that patients with AMI and AMA have higher possibilities of presenting heart failure and death. The aim of the present study was to determine if there is an association (odds ratio, OR) between AMA and death in patients with AMI. The design was a cross-sectional study. One hundred patients with acute myocardial infarction were recruited consecutively at the Coronary Care Unit of the Hospital de Especialidades at La Raza National Medical Center, IMSS, Mexico City. IgG antimyocardium antibodies were identified using the enzyme-linked immunosorbent assay technique (ELISA). Of the 100 patients studied, 81 were males and 19 females, with an average age of 58 +/- 11 years. Of the population studied, 44% showed AMA. It was observed that patients with positive AMA had an OR for heart failure of 3.40 (CI 95% 0.97-12.5, p = 0.06) and for death of 7.94 (CI 95%, 1.49-56.1, p = 0.003). T...Continue Reading

References

Mar 1, 1974·Circulation·M A EngleJ Zabriskie
Jul 9, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·H PangQ Lu

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Citations

Aug 18, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Charline Wehlou, Joris R Delanghe

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