Relation of augmented platelet reactivity to the magnitude of distribution of atherosclerosis

The American Journal of Cardiology
Friederike K KeatingDavid J Schneider

Abstract

The extent of luminal involvement of atherosclerotic vascular disease and platelet reactivity portend subsequent cardiovascular events. This study was designed to determine whether platelet reactivity correlates with the extent of the territorial distribution of vascular disease. Blood was obtained from 130 patients who had known atherosclerotic vascular disease categorized as being in > or =1 of the following territories: coronary artery disease (CAD; n = 89), cerebrovascular disease (n = 36), and peripheral arterial disease (n = 61). Platelet reactivity, i.e., the activation of platelets in response to a low concentration of adenosine diphosphate (0.2 micromol/L), was measured using flow cytometry. Patients with vascular disease in >1 territory compared with those with disease in only 1 territory had greater platelet reactivity with respect to P-selectin expression (p = 0.01). The percentages of platelets expressing P-selectin (mean +/- SD) were 6.4 +/- 4.2 in patients who had involvement of 1 territory (n = 88), 10.0 +/- 6.8 in those who had involvement of 2 territories (n = 28), and 10.1 +/- 9.9 in those who had involvement of 3 territories (n = 14). Patients who had CAD and diabetes mellitus had greater P-selectin expressi...Continue Reading

References

Jan 1, 1978·Atherosclerosis·A S WardW Morris-Jones
Feb 15, 1990·Thrombosis Research·H SinzingerP Fitscha
Oct 25, 2001·Lancet·K Ouriel
Jan 15, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P A RoblessG P Stansby
Jul 5, 2003·Journal of Vascular Surgery·K CassarJ Brittenden
Jul 25, 2003·Coronary Artery Disease·Naji YazbekNeal Kleiman
Dec 9, 2003·European Heart Journal·Andrew D BlannGregory Y H Lip

❮ Previous
Next ❯

Citations

Dec 29, 2012·Journal of Cardiovascular Translational Research·Fabio Mangiacapra, Emanuele Barbato
Dec 9, 2008·American Heart Journal·Muthiah VaduganathanEli I Lev
Mar 23, 2005·Current Opinion in Pharmacology·Burton E Sobel, David J Schneider
Jan 4, 2013·Journal of Cardiovascular Translational Research·Annunziata NuscaGermano Di Sciascio
Nov 14, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jamile F GonçalvesMaria Rosa C Schetinger
Jan 26, 2007·International Journal of Cardiology·Sze-Piaw ChinKui-Hian Sim
Oct 20, 2007·Journal of Thrombosis and Haemostasis : JTH·D S LeeE J Benjamin
Jun 20, 2006·Thrombosis Research·Wiktor KuliczkowskiWalentyna Mazurek
Jul 20, 2007·Circulation·David J Schneider, Burton E Sobel
Oct 16, 2013·Journal of Cardiopulmonary Rehabilitation and Prevention·Friederike K KeatingPhilip A Ades
May 22, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hao ZhouYuandong Peng
Jan 12, 2016·Coronary Artery Disease·David J Schneider, Sreedivya Chava
Aug 30, 2019·International Journal of Molecular Sciences·Kevin KojokYahye Merhi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.