Relation of baseline presence and severity of renal disease to long-term mortality in persons with known stroke

Journal of the Neurological Sciences
Chizobam Ani, Bruce Ovbiagele

Abstract

Little is known about the long-term prognostic impact of baseline chronic kidney disease (CKD) on outcomes after stroke. We assessed the association of diagnosis and severity of baseline CKD with risk of mortality among persons with a history of stroke. Data from the National Health and Nutrition Examination Survey (NHANES) a nationally representative sample of US adults were analyzed. The study population consisted of 425 individuals aged > or =55 years with a baseline history of stroke followed-up from NHANES III survey participation (1988-1994) through mortality assessment in 2000. CKD outcomes were glomerular filtration rate (GFR) <60 mL/min/1.73 m(2) and urinary albumin to creatinine ratio (UACR) >30 mg/g of creatinine. CKD severity was categorized per national guidelines. Proportional hazard regression (Cox) was utilized to explore the independent relationship between CKD vs. all-cause and cardiovascular mortality after adjusting for confounders. Among the cohort, 55.8% were female, 77.3% aged > or =65 years. Baseline serum creatinine was higher among persons with known stroke who later died vs. remained alive (p<0.01). Multivariable models showed that persons with low GFR (HR, 1.87 95% CI=1.30-2.68), CKD stages 1-2 (HR 1...Continue Reading

References

Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·B Modan, D K Wagener
Feb 1, 1991·Journal of Internal Medicine·P J Friedman
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·L E CorwinP M McNamara
Aug 1, 1995·Stroke; a Journal of Cerebral Circulation·P G O'MahonyR G Thomson
Dec 29, 1998·Annals of Internal Medicine·Donald Lloyd-JonesD Levy
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·T EngstadM Viitanen
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Ronald S MacWalterRouling Chen
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyNational Kidney Foundation
Apr 13, 2004·International Journal of Epidemiology·Matthew F YuyunEuropean Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population study
Sep 24, 2004·The New England Journal of Medicine·Nagesh S AnavekarMarc A Pfeffer
Mar 24, 2005·American Journal of Nephrology·Alain BaumelouGilbert Deray
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Marcello TonelliAmit X Garg
Dec 30, 2006·Circulation·Wayne RosamondAmerican Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 27, 2007·Stroke; a Journal of Cerebral Circulation·Kazim Sheikh, Claudia M Bullock
Feb 28, 2007·American Journal of Hypertension·David W BrownKurt J Greenlund
Apr 21, 2007·Stroke; a Journal of Cerebral Circulation·Angela M CarterPeter J Grant
Jul 4, 2007·Circulation·Ernesto L SchiffrinJohannes F E Mann
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·M Arfan IkramMonique M B Breteler
Jun 3, 2008·Journal of the Neurological Sciences·Bruce Ovbiagele
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Feb 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·George TsagalisKonstantinos N Vemmos

Citations

Jul 13, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Attilio LositoLuigi De Angelis
Oct 5, 2010·BMJ : British Medical Journal·Meng LeeBruce Ovbiagele
Oct 26, 2012·Expert Opinion on Drug Safety·Imtiaz SalimAmar M Salam
Apr 10, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meng LeeBruce Ovbiagele
Jun 15, 2011·The American Journal of Emergency Medicine·Alfredo De GiorgiRoberto Manfredini
Nov 26, 2010·Journal of the Neurological Sciences·Bruce Ovbiagele
Mar 8, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Danni ZhengINTERACT2 Investigators
Feb 13, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T KuwashiroT Kitazono
Jan 11, 2013·European Journal of Clinical Investigation·Sharmini SelvarajahSMART study group
May 9, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fabio FabbianRoberto Manfredini
Jun 7, 2014·Journal of the American Heart Association·Bruce OvbiageleGregg C Fonarow
Feb 11, 2011·Expert Review of Neurotherapeutics·Meng Lee, Bruce Ovbiagele

Related Concepts

Albuminuria
Cardiovascular Diseases
Krebiozen
Glomerular Filtration Rate
Kidney Diseases
Kidney Function Tests
Regression Analysis
Comorbidity
Survival Analysis
Acute Cerebrovascular Accidents

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