Relation of body mass index to mortality among men with coronary heart disease

The American Journal of Cardiology
Michal BenderlyUri Goldbourt

Abstract

Reports among patients with coronary heart disease regarding the association between body mass index (BMI) and long-term mortality are inconsistent, ranging among linear, U-shaped, or inverse (the "obesity paradox") associations. BMI and mortality data were available for 12,466 men with chronic coronary heart disease. BMI was classified as <20 (lean), 20.0 to 22.99, 23.0 to 24.99 (reference), 25.0 to 26.99, 27.0 to 29.99, and >or=30 kg/m(2) (obese). Age-adjusted (direct methods) mortality was investigated within risk factor categories. Adjusted hazard ratios compared with the reference group were estimated using a Cox proportional-hazards model. Two thirds of the patients had BMIs >or=25 kg/m(2). A number of risk factors were progressively more frequent with increasing BMI (age, diabetes, past smoking, and metabolic components). Over a median follow-up period of 12 years, adjusted mortality rates per 1,000 patient-years followed a U-shaped association with BMI. The highest risk was noted in 148 lean (hazard ratio 1.41, 95% confidence interval 1.08 to 1.85) and 1,788 obese (hazard ratio 1.28, 95% confidence interval 1.15 to 1.42) patients. Mortality hazard in patients with BMIs of 20.0 to 29.99 kg/m(2) (84% of patients) did not ...Continue Reading

References

Aug 5, 1999·The New England Journal of Medicine·W C WillettG A Colditz
Jan 8, 2000·The New England Journal of Medicine·G N ThomasJ A Critchley
Jul 6, 2000·Circulation·UNKNOWN Bezafibrate Infarction Prevention (BIP) study
Aug 7, 2002·International Journal of Cardiology·Stefan D Anker, Rakesh Sharma
Dec 6, 2003·Circulation Research·V Planat-BénardL Casteilla
Jan 18, 2005·Annals of Epidemiology·Daniel L McGee, UNKNOWN Diverse Populations Collaboration
Apr 26, 2006·The American Journal of Cardiology·Ronen RubinshteinBasil S Lewis
Sep 26, 2006·The American Journal of Cardiology·Amit HabbuHisham Dokainish
May 29, 2007·The American Journal of Cardiology·Wael GalalDon Poldermans
Oct 17, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Harm WienbergenUNKNOWN MITRA PLUS study group
Jul 22, 2008·Chest·Wael GalalDon Poldermans

❮ Previous
Next ❯

Citations

Jan 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A LintermansP Neven
Mar 25, 2014·Current Atherosclerosis Reports·Harold Bays
Nov 15, 2011·Thrombosis Research·Paul D SteinJose Goldman
Nov 26, 2010·The American Journal of Cardiology·Carl J LavieHector O Ventura
Jan 17, 2013·Journal of the American Society of Hypertension : JASH·Steven G Chrysant, George S Chrysant
Dec 30, 2011·International Journal of Cardiology·Elisabet ZamoraAntoni Bayés-Genís
Jun 9, 2016·Journal of cardiology·Yohei NumasawaKeiichi Fukuda
Jul 14, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S AntonopoulosD Tousoulis
Dec 12, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Esme Fuller-Thomson, Angela D Dalton
Jun 2, 2011·Journal of Aging and Health·Maria Victoria ZunzuneguiAngel Otero
May 27, 2017·Cardiovascular Research·Alexios S Antonopoulos, Dimitris Tousoulis
May 25, 2011·Circulation·Barry A Franklin, Mary Cushman
Feb 27, 2018·Nutrition Journal·Xuling ChangChew-Kiat Heng
Nov 6, 2010·Molecular Ecology·Tyler S Kuhn, Arne Ø Mooers
Oct 21, 2011·Arquivos brasileiros de endocrinologia e metabologia·J B DixonUNKNOWN International Diabetes Federation Taskforce on Epidemiology and Prevention
Jul 31, 2019·Journal of the Saudi Heart Association·Jan-Erik GuelkerWilfried Dinh
Nov 24, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Xinxing FengLei Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.