PMID: 3748273Jul 1, 1986Paper

Relation of brain regional physostigmine concentration to cholinesterase activity and acetylcholine and choline levels in rat

Neurochemical Research
M Hallak, E Giacobini

Abstract

The relationship between physostigmine (Phy) concentration, acetylcholine (ACh), choline (Ch) and cholinesterase (ChE) activity was examined in whole rat brain after the administration of [3H]Phy (650 microgram/kg i.m.). Cholinesterase inhibition was found to be inversely related to Phy levels. Maximal inhibition (80%) was seen at 5 min and by 2 hrs ChE activity had returned to control levels. Acetylcholine levels in whole brain peaked at 30 min at a concentration (80 nmol/g) 2.3 times higher than controls (33 nmol/g). Choline levels were not significantly altered. The regional distribution of Phy concentration and ChE activity was studied in six areas of the brain following i.m. administration of three different dosages of ( 3H]Phy. Physostigmine concentration and ChE activity showed a dose dependency in each area examined except in SP (medial septum). Striatum (ST) showed the greatest relative increase of ACh up to 30 min, when compared to other areas. Choline levels were not changed in any area with the exception of ST at 5 min where a decrease was seen. There was a relationship between ChE activity, Phy concentration and ACh levels in all areas examined with exception of the medulla oblongata (MO). Our results indicate that...Continue Reading

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Citations

Aug 15, 1995·Journal of Neuroscience Research·X D Zhu, E Giacobini
Jun 1, 1990·Aging : Clinical and Experimental Research·M PomponiM Brufani
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yehuda ShavitBenzion Beilin
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Jun 1, 1987·Neuropharmacology·M Hallak, E Giacobini
Mar 1, 1993·Neuropharmacology·E MessamoreE Giacobini
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·J G Clement
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Apr 14, 2000·Behavioural Brain Research·S SarkarK P Mohanakumar
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