Relation of cardiac troponin I measurements at 24 and 48 hours to magnetic resonance-determined infarct size in patients with ST-elevation myocardial infarction

The American Journal of Cardiology
Jonas HallénDan Atar

Abstract

Levels of circulating cardiac troponin I (cTnI) or T are correlated to extent of myocardial destruction after an acute myocardial infarction. Few studies analyzing this relation have employed a second-generation cTnI assay or cardiac magnetic resonance (CMR) as the imaging end point. In this post hoc study of the Efficacy of FX06 in the Prevention of Mycoardial Reperfusion Injury (F.I.R.E.) trial, we aimed at determining the correlation between single-point cTnI measurements and CMR-estimated infarct size at 5 to 7 days and 4 months after a first-time ST-elevation myocardial infarction (STEMI) and investigating whether cTnI might provide independent prognostic information regarding infarct size at 4 months even taking into account early infarct size. Two hundred twenty-seven patients with a first-time STEMI were included in F.I.R.E. All patients received primary percutaneous coronary intervention within 6 hours from onset of symptoms. cTnI was measured at 24 and 48 hours after admission. CMR was conducted within 1 week of the index event (5 to 7 days) and at 4 months. Pearson correlations (r) for infarct size and cTnI at 24 hours were r = 0.66 (5 days) and r = 0.63 (4 months) and those for cTnI at 48 hours were r = 0.67 (5 days...Continue Reading

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Citations

May 22, 2013·European Heart Journal Cardiovascular Imaging·Benoy Nalin Shah
Sep 28, 2013·European Heart Journal Cardiovascular Imaging·Jacob Lønborg, Thomas Engstrøm
Jul 30, 2011·Future Cardiology·Jonathan W Waks, Benjamin M Scirica
May 2, 2014·The International Journal of Cardiovascular Imaging·Elena GuerraAdnan Kastrati
May 25, 2010·The American Journal of Cardiology·Olivier F BertrandUNKNOWN EArly Discharge after Transradial Stenting of CoronarY Arteries in Acute Myocardial Infarction (EASY-MI) Study Investigators
Oct 30, 2012·International Journal of Cardiology·Beatriz Cepeda-ValeryAbel Romero-Corral
Jul 9, 2016·Journal of Cardiovascular Pharmacology and Therapeutics·Grete SlettomJan E Nordrehaug
Dec 25, 2017·Journal of the American Heart Association·Germán CedielAntoni Bayes-Genis
Oct 11, 2011·Circulation. Arrhythmia and Electrophysiology·Michifumi TokudaUsha B Tedrow
Jul 1, 2016·European Heart Journal. Quality of Care & Clinical Outcomes·Tuan L NguyenLiza Thomas
Mar 27, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Allie E GoinsGeorge A Stouffer
Jun 27, 2021·Annals of Emergency Medicine·Kenneth W DoddUNKNOWN PERFECT study investigators (the complete list of PERFECT study investigators is provided in Appendix E1, available at http:

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