PMID: 3412371Sep 1, 1988Paper

Relation of changes in amount and type of dietary fat to fecapentaenes in premenopausal women

Mutation Research
P R TaylorG Block

Abstract

Correlation studies suggest that fecal mutagenicity is increased in groups eating high-fat diets, the same groups who are often found to have high colorectal cancer incidence and mortality. The fecapentaenes are the best characterized class of fecal mutagens, but the relationship of dietary fat intake to the excretion of these potent genotoxins is unknown. We studied the effect of changes in amount and type of dietary fat on fecapentaene levels in 31 premenopausal women 20-40 years of age who participated in a controlled feeding study. After a pre-diet free-living period lasting 1 menstrual cycle, women were placed on a high-fat (40% energy from fat) diet for 4 menstrual cycles and then switched to a low-fat (20% energy from fat) diet for an additional 4 menstrual cycles. One-half the subjects were maintained throughout the study at a ratio of polyunsaturated-to-saturated fatty acids (P/S ratio) of 1.0, the other half at 0.3; body weight was constant. All meals during the controlled diet periods were prepared at the Human Study Facility of the Beltsville Human Nutrition Research Center. Fecapentaene and fecapentaene precursor levels were measured in acetone extracts from 3-day pooled stool samples collected during the study. No...Continue Reading

Citations

Mar 1, 1991·Mutation Research·A C PoveyC C Harris
Sep 16, 1992·Journal of Chromatography·T M de KokJ C Kleinjans
Jun 6, 2000·Mutation Research·T M de Kok, J M van Maanen
Mar 1, 1989·Preventive Medicine·P R TaylorD Albanes
Sep 1, 1992·Cancer·P Greenwald
Oct 20, 2005·Age and Ageing·Catherine W McGrotherUNKNOWN Leicestershire MRC Incontinence Study Team
Sep 15, 1990·International Journal of Cancer. Journal International Du Cancer·P P NairP R Taylor

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