Relation of Concomitant Heart Failure to Outcomes in Patients Hospitalized With Influenza

The American Journal of Cardiology
Muhammad S PanhwarMahazarin Ginwalla

Abstract

Influenza is a major public health challenge. Patients hospitalized with influenza who also have heart failure (HF) may be at risk for worse outcomes compared with patients without HF. There is a lack of large studies examining this issue. We queried the 2013 to 2014 National Inpatient Sample for all adult patients (aged ≥ 18 years) admitted with influenza with and without concomitant HF. Using propensity score matching, patients were matched across demographics, discharge weights, and comorbidities. Outcomes included in-hospital mortality, complications, length of stay, and average hospital costs. Of 218,540 influenza hospitalizations, 45,460 (20.8%) had concomitant HF. Patients with HF had higher in-hospital mortality (6.1% vs 3.8%, adjusted odds ratio [aOR] 1.66 [95% confidence interval [CI] 1.44 to 1.91]; p <0.001), acute kidney injury (29.5% vs 22.2%, aOR 1.47 [95% CI 1.37 to 1.57]; p <0.001), acute kidney injury requiring dialysis (2.0% vs 1.0%, aOR 2.08 [1.62 to 2.67], acute respiratory failure (36.2% vs 23.5%, aOR 1.85 [1.73 to 1.97]; p <0.001), and acute respiratory failure requiring mechanical ventilation (17.1% vs 9.3%, OR 2.01 [1.84 to 2.21]; p <0.001), longer length of stay (5.70 ± 0.02 days vs 4.60 ± 0.01 days, p ...Continue Reading

Citations

Jan 11, 2020·Critical Care Medicine·Chang GaoUNKNOWN for the Community-Acquired Pneumonia–China Network
Oct 1, 2019·Current Opinion in Nephrology and Hypertension·Dana C Miskulin
Aug 25, 2020·Current Tropical Medicine Reports·Lucia Gutiérrez-SpillariJorge Aceituno-Melgar
Mar 25, 2020·Critical Care Medicine·Chang GaoUNKNOWN Community-Acquired Pneumonia–China Network
Dec 19, 2020·BMC Medicine·Muhammad Shahzeb KhanJaved Butler
Jul 2, 2021·Journal of Family Medicine and Primary Care·Smitesh GuttaThambu David Sudarsanam
Oct 20, 2020·The American Journal of Emergency Medicine·Emir YonasSalim S Virani
Aug 25, 2021·Influenza and Other Respiratory Viruses·Sindhaghatta VenkatramGilda Diaz-Fuentes
Oct 6, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Paul J HansonBruce M McManus

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