Relation of delayed recovery of myocardial function after takotsubo cardiomyopathy to subsequent quality of life

The American Journal of Cardiology
Christopher J NeilJohn D Horowitz

Abstract

Takotsubo cardiomyopathy (TTC) has generally been regarded as a relatively transient disorder, characterized by reversible regional left ventricular systolic dysfunction. However, most patients with TTC experience prolonged lassitude or dyspnea after acute attacks. Although this might reflect continued emotional stress, myocardial inflammation and accentuated brain-type natriuretic peptide (BNP) release persist for at least 3 months. We therefore tested the hypotheses that this continued inflammation is associated with (1) persistent contractile dysfunction and (2) consequent impairment of quality of life. Echocardiographic parameters (global longitudinal strain [GLS], longitudinal strain rate [LSR], and peak apical twist [AT]) were compared acutely and after 3 months in 36 female patients with TTC and 19 age-matched female controls. Furthermore, correlations were sought between putative functional anomalies, inflammatory markers (T2 score on cardiovascular magnetic resonance, plasma NT-proBNP, and high-sensitivity C-reactive protein levels), and the physical composite component of SF36 score (SF36-PCS). In TTC cases, left ventricular ejection fraction returned to normal within 3 months. GLS, LSR, and AT improved significantly ...Continue Reading

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Citations

May 26, 2016·European Journal of Heart Failure·Kuljit Singh
Jul 15, 2016·Nature Reviews. Cardiology·Julian O M OrmerodMark V Sherrid
Sep 18, 2016·Heart Failure Clinics·Andrew C Morley-Smith, Alexander R Lyon
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Sep 11, 2019·Aesthetic Surgery Journal·Sebastiaan MaesKoenraad Van Landuyt
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Aug 1, 2018·JACC. Basic to Translational Science·Sven Y SurikowJohn D Horowitz
Jan 10, 2019·JACC. Basic to Translational Science·Heather M WilsonDana K Dawson
Jan 4, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Adil WaniBijoy K Khandheria
Mar 18, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Kenan YaltaTulin Yalta
Mar 25, 2021·ESC Heart Failure·Gao Jing OngJohn David Horowitz
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May 28, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Kihei Yoneyama, Yoshihiro J Akashi

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