Relation of endothelial function to residual platelet reactivity after clopidogrel in patients with stable angina pectoris undergoing percutaneous coronary intervention

The American Journal of Cardiology
Olivier MullerEmanuele Barbato

Abstract

Platelet reactivity is greater in patients with stable angina and with more extensive peripheral vascular atherosclerosis. We sought to evaluate whether impaired peripheral microcirculatory endothelial function might correlate with platelet reactivity after clopidogrel and therefore predispose to an unfavorable outcome after percutaneous coronary intervention (PCI). In 52 consecutive patients with stable angina undergoing elective PCI, endothelial function was assessed by (1) endothelial peripheral arterial tonometry (measuring the "Endoscore"); (2) the von Willebrandt factor antigen level and ristocetin co-factor activity. Basal platelet reactivity was assessed by soluble P-selectin. Patients then received a 600-mg clopidogrel loading dose > or = 12 hours before PCI. A blood sample was withdrawn 12 hours later, but before PCI, to assess platelet reactivity using the P2Y12 reaction unit and percentage of P2Y12 inhibition with the point-of-care VerifyNow P2Y12 assay. Troponin T was assessed 24 hours after PCI. The Endoscore inversely correlated with von Willebrandt factor antigen activity (r = -0.52, p = 0.0001) and soluble P-selectin concentration (r = -0.36, p = 0.021), suggesting greater platelet reactivity with increased imp...Continue Reading

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Citations

Jan 12, 2013·Journal of Cardiovascular Translational Research·Jozef BartunekJosefin-Beate Holz
Dec 29, 2012·Journal of Cardiovascular Translational Research·Fabio Mangiacapra, Emanuele Barbato
Mar 30, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Luigi Di SerafinoEmanuele Barbato
Dec 13, 2012·Journal of Cardiovascular Translational Research·Olivier MullerEmanuele Barbato
Feb 4, 2011·Journal of Thrombosis and Thrombolysis·Michalis HamilosEmanuele Barbato
Apr 26, 2014·Current Atherosclerosis Reports·Teresa StrisciuglioGennaro Galasso
Oct 15, 2014·Clinical and Experimental Pharmacology & Physiology·Yin-Zhuang ZhangXin Cao
Feb 17, 2018·Journal of Thrombosis and Thrombolysis·Fabio MangiacapraGermano Di Sciascio
Aug 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Petra KleinbongardGerd Heusch

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