Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans

American Journal of Hypertension
Rongling LiElizabeth Ofili

Abstract

The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NOx) level, endothelial function, and blood pressure (BP) remains unclear. We estimated the relationship of eNOS polymorphisms (the T(-786)C in the 5'-flanking promoter region, T(-786)C; 27-bp repeat in intron 4, eNOS4; and Glu298Asp in exon 7, G894T) with plasma NOx level, brachial endothelial function assessed by ultrasound measure of brachial artery flow-mediated dilation (FMD), and BP in 60 healthy African Americans, 30 men and 30 women aged 18 to 73 years. Among them, 73.1%, 23.9%, and 3.0% carried TT, TC, and CC of T(-786)C, respectively, 14.5%, 27.5%, 53.6%, and 1.4% carried aa, ab, bb, and bc of eNOS4 polymorphism, respectively, and 70.4%, 23.9%, and 5.6% carried GG, GT, and TT of G894T, respectively. G894T and eNOS4 were observed in linkage disequilibrium. Mean values of age, plasma NOx, FMD, systolic and diastolic BPs were not significantly different (P >.05) by eNOS polymorphisms. Plasma NO(x) level was found to be associated with systolic BP (r = 0.51, P =.03), and diastolic BP (r = 0.41, P =.08), but not with FMD, in individuals with "a" allele of eNOS4 polymorphism after adjustment for age, body mass index, serum glucose, and smoking status. We reve...Continue Reading

Citations

May 14, 2009·DNA and Cell Biology·Marcelo R LuizonJose E Tanus-Santos
Jan 24, 2008·Reproductive Sciences·Eugenia Mata-Greenwood, Dong-Bao Chen
Jun 23, 2010·BMC Genetics·Norma C SerranoMaría C Páez
Jun 2, 2011·Future Cardiology·Nicholas B Norgard, Gina M Prescott
May 1, 2009·Indian Journal of Human Genetics·Sushma PatkarT Padma
Feb 13, 2013·Gene Regulation and Systems Biology·Bolaji N ThomasJurg Ott
Dec 29, 2009·Journal of Atherosclerosis and Thrombosis·Vijaya MajumdarRita Christopher
Jul 6, 2014·Oxidative Medicine and Cellular Longevity·Gregorio CaimiEugenia Hopps
Aug 2, 2011·Archives of Physiology and Biochemistry·Tiago M RezendeAngelina Zanesco
Sep 21, 2013·Human Fertility : Journal of the British Fertility Society·W Y AlmawiR R Finan
Aug 29, 2014·BioMed Research International·Priyanka ShankarishanJagadish Mahanta
Aug 9, 2016·High Altitude Medicine & Biology·Martin J MacInnis, Michael S Koehle
Apr 27, 2013·Acta Ophthalmologica·Giacomo CavallaroFabio Mosca
Dec 18, 2007·Journal of Clinical Pharmacology·L Michael Prisant
Sep 9, 2005·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Wylie Burke
Jun 10, 2010·The Pharmacogenomics Journal·I F MetzgerJ E Tanus-Santos
Oct 6, 2005·Hypertension·Emily M GarlandDavid Robertson
Aug 2, 2007·Critical Pathways in Cardiology·Keith C Ferdinand, Annemarie M Armani
Apr 8, 2006·Current Hypertension Reports·Gordon S Stokes
Jul 9, 2010·European Journal of Applied Physiology·Anderson Saranz ZagoMichael D Brown
Aug 12, 2005·Journal of the American Society of Nephrology : JASN·Andrea PageJudith A Miller
Oct 28, 2004·Nature Genetics·Sarah K Tate, David B Goldstein
Feb 17, 2006·Current Opinion in Nephrology and Hypertension·Martin W McBrideAnna F Dominiczak
Oct 5, 2006·American Journal of Epidemiology·Juan P CasasAroon D Hingorani
Jun 28, 2014·Clinical Journal of the American Society of Nephrology : CJASN·David A DrewMark J Sarnak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.