Relation of endothelium, thrombogenesis, and hemorheology in systemic hypertension to ethnicity and left ventricular hypertrophy

The American Journal of Cardiology
G Y LipD G Beevers

Abstract

Although the arterial tree is exposed to increased pressure in hypertensive patients, paradoxically, the complications of hypertension (heart attacks, stroke) are mainly thrombotic rather than hemorrhagic. Patients with left ventricular (LV) hypertrophy are at high risk of the complications of hypertension. We performed a cross-sectional study of 178 patients attending a hypertension clinic in a city center teaching hospital, and measured plasma levels of the soluble adhesion molecule P-selectin (associated with platelet activity/function and atherosclerosis), the von Willebrand factor (vWf; a marker of endothelial dysfunction), fibrin D-dimer (an index of thrombogenesis), plasminogen activator inhibitor (PAI, an index of fibrinolysis), lipoprotein(a) (Lp(a), associated with thrombogenesis and atherogenesis) and hemorheological indexes (fibrinogen, hematocrit, plasma viscosity, hemoglobin) in patients with essential hypertension, in whom the LV mass and LV mass index were determined using echocardiography. The 178 patients (86 men, mean age 54 +/- 15 years) were compared with 47 normotensive healthy controls (aged 56 +/- 20 years). Hypertensive patients had higher P-selectin, PAI, vWf, fibrin D-dimer, Lp(a), plasma fibrinogen, ...Continue Reading

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Citations

Jun 26, 2001·European Journal of Haematology·N KametasK H Nicolaides
Apr 4, 2001·Journal of Internal Medicine·G Y LipD G Beevers
Feb 5, 2005·Pathophysiology of Haemostasis and Thrombosis·Irene Chung, Gregory Y H Lip
Dec 4, 2003·Thrombosis Research·Thomas K MakrisVassilios V Votteas
Oct 16, 2002·Current Cardiology Reports·Lwin Lwin TinGregory Y H Lip
Oct 8, 2009·International Heart Journal·Borut JugIrena Keber
Mar 11, 2011·Blood Pressure·D P PapadopoulosT K Makris
Sep 22, 2012·The American Journal of Cardiology·Peter J LearySteven M Kawut
Mar 25, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S BoP Cavallo-Perin
Mar 1, 2011·Journal of Ethnopharmacology·Eun Ji SeoYi-Sook Jung
Jul 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·G BrunoP Cavallo Perin
Jun 20, 2003·European Journal of Clinical Investigation·C ZoccaliM Buemi
Jun 21, 2012·Clinical and Experimental Hypertension : CHE·Dimitris PapadopoulosThomas Makris
Oct 1, 2013·Expert Opinion on Therapeutic Targets·Silvia Montoro-GarcíaGregory Y H Lip
Apr 6, 2002·The Journal of the American Dental Association·Michael Glick
Mar 26, 2003·Journal of the American College of Cardiology·Mark A EastEric D Peterson
May 28, 2003·Journal of the American College of Cardiology·Sunil Nadar, Gregory Y H Lip
Oct 14, 2003·Chest·Jason D ChristieStephen E Kimmel
Jan 23, 2010·American Journal of Hypertension·Eugenia GkaliagkousiAlbert Ferro
Feb 6, 2013·American Journal of Hypertension·Cristiana CatenaLeonardo A Sechi
May 19, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paolo VerdecchiaGiuseppe Di Pasquale
May 11, 2007·Expert Review of Cardiovascular Therapy·Puneet Kakar, Gregory Y H Lip
Apr 12, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ender Arikan, Saniye Sen
Jun 26, 2002·Journal of Human Hypertension·G Y H LipD G Beevers
Jan 28, 2005·Journal of Human Hypertension·D C Felmeden, G Y H Lip
Jul 10, 2002·Hypertension·Charles G C SpencerUNKNOWN ASCOT Steering Committee, Anglo-Scandinavian Cardiac Outcomes Trial

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