Relation of epicardial fat thickness to right ventricular cavity size in obese subjects

The American Journal of Cardiology
Gianluca Iacobellis

Abstract

Epicardial fat is the visceral fat depot of the heart and is commonly increased in obese subjects. Obesity is also associated with right ventricular (RV) enlargement. Nevertheless, whether epicardial fat might be independently associated with RV morphology is unknown. I evaluated the correlation between echocardiographic epicardial fat and RV cavity size in subjects with a wide range of adiposity. Echocardiographic epicardial fat thickness and RV end-diastolic diameter (RVEDD) were assessed in 50 obese and 50 normal weight subjects. Patients with clinical conditions that could affect the RVEDD were excluded. Obese subjects had a significantly greater epicardial fat thickness and RVEDD than normal weight subjects (10 +/- 4 vs 5 +/- 2 mm and 22 +/- 10 vs 15 +/- 5, respectively; p <0.01 for both). The univariate relation between the epicardial fat thickness and RVEDD was very significant (r = 0.82, p <0.01) for overall obese and normal weight subjects. Multiple regression analysis showed that epicardial fat thickness was the best independent correlate of RVEDD (r(2) = 0.42, p <0.01) in overall subjects. In conclusion, increased RV epicardial fat accumulation is associated with enlarged RV cavity size.

References

Aug 16, 2002·Obesity Research·Gianluca IacobellisFrida Leonetti
Feb 13, 2003·Obesity Research·Gianluca IacobellisFrida Leonetti
Oct 13, 2004·The American Journal of Cardiology·Gianluca IacobellisFrida Leonetti
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Citations

Nov 26, 2013·Endocrine·Gianluca Iacobellis
Nov 3, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Marcos M Lima-MartínezGianluca Iacobellis
Jun 12, 2010·The American Journal of Cardiology·Alexis Elias MalavazosGianluca Iacobellis
Aug 19, 2010·Journal of Cellular and Molecular Medicine·D Margriet OuwensJuergen Eckel
Apr 9, 2015·Nature Reviews. Endocrinology·Gianluca Iacobellis
Aug 20, 2011·Trends in Endocrinology and Metabolism : TEM·Gianluca Iacobellis, Antonio C Bianco
Jun 26, 2012·International Journal of Cardiology·Stefania MarianiLucio Gnessi
Apr 23, 2011·Journal of the American College of Cardiology·Christopher X WongPrashanthan Sanders
Jul 28, 2017·Nature Reviews. Cardiology·Carl J LavieHector O Ventura
Jul 1, 2009·Expert Opinion on Pharmacotherapy·Angelo Iacobellis, Angelo Andriulli

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