PMID: 9443661Jan 27, 1998Paper

Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Sulev KõksP T Männistö

Abstract

Forty-five male Wistar rats were selected according to their behavior in the elevated plus-maze. They were separated as follows: animals with low exploratory activity ('anxious'), an 'intermediate' group and animals having high exploratory activity ('non-anxious'). Various receptor binding studies and hormonal assays were also performed in these selected rats. The affinity of 5-hydroxytryptamine 5-HT2A receptors in the frontal cortex was lower in the 'anxious' rats compared to home-cage controls and 'non-anxious' animals. Moreover, the number of cholecystokinin (CCK) receptors in the hippocampus was significantly elevated in the 'anxious' group compared to home-cage control animals. The blood levels of growth hormone (GH) were significantly lower in the 'non-anxious' rats compared to 'anxious' counterparts. In conclusion, it seems likely that the decreased exploratory activity of rats is related to the increased 5-hydroxytryptamine (5-HT) and CCK mediated neurotransmission in the brain. The different serum levels of GH in the selected rats probably reflect alterations in the activity of 5-HT and CCK.

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Citations

Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Qian ChenYa-Ping Tang
Aug 27, 2005·Neuroscience and Biobehavioral Reviews·Hong WangYi Zhun Zhu
Dec 20, 2007·Human Psychopharmacology·Annemarie HeberleinThomas Hillemacher

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